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Carvacrol and PPARγ agonist, pioglitazone, affects inhaled paraquat-induced lung injury in rats
Exposed rats to normal saline and paraquat (PQ) aerosol as control and PQ group, rats exposed to PQ and treated with 20 and 80 mg/kg/day carvacrol, 5 and 10 mg/kg/day pioglitazone, low dose of pioglitazone + carvacrol and 0.03 mg/kg/day dexamethasone (Dexa) for 16 days after the end of PQ exposure w...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047048/ https://www.ncbi.nlm.nih.gov/pubmed/33854134 http://dx.doi.org/10.1038/s41598-021-87546-8 |
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author | Amin, Fatemeh Memarzia, Arghavan Rad, Hamideh Kazemi Kazerani, Hamid Reza Boskabady, Mohammad Hossein |
author_facet | Amin, Fatemeh Memarzia, Arghavan Rad, Hamideh Kazemi Kazerani, Hamid Reza Boskabady, Mohammad Hossein |
author_sort | Amin, Fatemeh |
collection | PubMed |
description | Exposed rats to normal saline and paraquat (PQ) aerosol as control and PQ group, rats exposed to PQ and treated with 20 and 80 mg/kg/day carvacrol, 5 and 10 mg/kg/day pioglitazone, low dose of pioglitazone + carvacrol and 0.03 mg/kg/day dexamethasone (Dexa) for 16 days after the end of PQ exposure were studied (n = 6 in each group). Lung pathological changes, tracheal responsiveness to methacholine and ovalbumin (OVA) as well as transforming growth factor beta (TGF-β) and interleukin (IL)-6 level in the lung tissue homogenize as well as TGF-β, IL-6, oxidant and antioxidant levels oxidant and antioxidants were increased in PQ group (p < 0.01 to p < 0.001). Lung pathological changes, tracheal responsiveness to methacholine and OVA as well as TGF-β, IL-6 oxidant and antioxidant levels were improved in all treated groups except lung pathological changes in treated group with low dose of pioglitazone (p < 0.05 to p < 0.001). The effects of low dose of pioglitazone and carvacrol alone were significantly lower than in the combination group of low dose of pioglitazone + carvacrol (p < 0.05 to p < 0.001). Carvacrol treatment improved inhaled PQ-induced lug injury similar to the effects of dexamethasone. The synergic effect of carvacrol and pioglitazone suggests PPAR-γ receptor mediated effects of carvacrol on inhaled PQ-induced lung injury. |
format | Online Article Text |
id | pubmed-8047048 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-80470482021-04-15 Carvacrol and PPARγ agonist, pioglitazone, affects inhaled paraquat-induced lung injury in rats Amin, Fatemeh Memarzia, Arghavan Rad, Hamideh Kazemi Kazerani, Hamid Reza Boskabady, Mohammad Hossein Sci Rep Article Exposed rats to normal saline and paraquat (PQ) aerosol as control and PQ group, rats exposed to PQ and treated with 20 and 80 mg/kg/day carvacrol, 5 and 10 mg/kg/day pioglitazone, low dose of pioglitazone + carvacrol and 0.03 mg/kg/day dexamethasone (Dexa) for 16 days after the end of PQ exposure were studied (n = 6 in each group). Lung pathological changes, tracheal responsiveness to methacholine and ovalbumin (OVA) as well as transforming growth factor beta (TGF-β) and interleukin (IL)-6 level in the lung tissue homogenize as well as TGF-β, IL-6, oxidant and antioxidant levels oxidant and antioxidants were increased in PQ group (p < 0.01 to p < 0.001). Lung pathological changes, tracheal responsiveness to methacholine and OVA as well as TGF-β, IL-6 oxidant and antioxidant levels were improved in all treated groups except lung pathological changes in treated group with low dose of pioglitazone (p < 0.05 to p < 0.001). The effects of low dose of pioglitazone and carvacrol alone were significantly lower than in the combination group of low dose of pioglitazone + carvacrol (p < 0.05 to p < 0.001). Carvacrol treatment improved inhaled PQ-induced lug injury similar to the effects of dexamethasone. The synergic effect of carvacrol and pioglitazone suggests PPAR-γ receptor mediated effects of carvacrol on inhaled PQ-induced lung injury. Nature Publishing Group UK 2021-04-14 /pmc/articles/PMC8047048/ /pubmed/33854134 http://dx.doi.org/10.1038/s41598-021-87546-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Amin, Fatemeh Memarzia, Arghavan Rad, Hamideh Kazemi Kazerani, Hamid Reza Boskabady, Mohammad Hossein Carvacrol and PPARγ agonist, pioglitazone, affects inhaled paraquat-induced lung injury in rats |
title | Carvacrol and PPARγ agonist, pioglitazone, affects inhaled paraquat-induced lung injury in rats |
title_full | Carvacrol and PPARγ agonist, pioglitazone, affects inhaled paraquat-induced lung injury in rats |
title_fullStr | Carvacrol and PPARγ agonist, pioglitazone, affects inhaled paraquat-induced lung injury in rats |
title_full_unstemmed | Carvacrol and PPARγ agonist, pioglitazone, affects inhaled paraquat-induced lung injury in rats |
title_short | Carvacrol and PPARγ agonist, pioglitazone, affects inhaled paraquat-induced lung injury in rats |
title_sort | carvacrol and pparγ agonist, pioglitazone, affects inhaled paraquat-induced lung injury in rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047048/ https://www.ncbi.nlm.nih.gov/pubmed/33854134 http://dx.doi.org/10.1038/s41598-021-87546-8 |
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