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Increased Brain Age Gap Estimate (BrainAGE) in Young Adults After Premature Birth

Recent evidence suggests increased metabolic and physiologic aging rates in premature-born adults. While the lasting consequences of premature birth on human brain development are known, its impact on brain aging remains unclear. We addressed the question of whether premature birth impacts brain age...

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Autores principales: Hedderich, Dennis M., Menegaux, Aurore, Schmitz-Koep, Benita, Nuttall, Rachel, Zimmermann, Juliana, Schneider, Sebastian C., Bäuml, Josef G., Daamen, Marcel, Boecker, Henning, Wilke, Marko, Zimmer, Claus, Wolke, Dieter, Bartmann, Peter, Sorg, Christian, Gaser, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047054/
https://www.ncbi.nlm.nih.gov/pubmed/33867970
http://dx.doi.org/10.3389/fnagi.2021.653365
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author Hedderich, Dennis M.
Menegaux, Aurore
Schmitz-Koep, Benita
Nuttall, Rachel
Zimmermann, Juliana
Schneider, Sebastian C.
Bäuml, Josef G.
Daamen, Marcel
Boecker, Henning
Wilke, Marko
Zimmer, Claus
Wolke, Dieter
Bartmann, Peter
Sorg, Christian
Gaser, Christian
author_facet Hedderich, Dennis M.
Menegaux, Aurore
Schmitz-Koep, Benita
Nuttall, Rachel
Zimmermann, Juliana
Schneider, Sebastian C.
Bäuml, Josef G.
Daamen, Marcel
Boecker, Henning
Wilke, Marko
Zimmer, Claus
Wolke, Dieter
Bartmann, Peter
Sorg, Christian
Gaser, Christian
author_sort Hedderich, Dennis M.
collection PubMed
description Recent evidence suggests increased metabolic and physiologic aging rates in premature-born adults. While the lasting consequences of premature birth on human brain development are known, its impact on brain aging remains unclear. We addressed the question of whether premature birth impacts brain age gap estimates (BrainAGE) using an accurate and robust machine-learning framework based on structural MRI in a large cohort of young premature-born adults (n = 101) and full-term (FT) controls (n = 111). Study participants are part of a geographically defined population study of premature-born individuals, which have been followed longitudinally from birth until young adulthood. We investigated the association between BrainAGE scores and perinatal variables as well as with outcomes of physical (total intracranial volume, TIV) and cognitive development (full-scale IQ, FS-IQ). We found increased BrainAGE in premature-born adults [median (interquartile range) = 1.4 (−1.3–4.7 years)] compared to full-term controls (p = 0.002, Cohen’s d = 0.443), which was associated with low Gestational age (GA), low birth weight (BW), and increased neonatal treatment intensity but not with TIV or FS-IQ. In conclusion, results demonstrate elevated BrainAGE in premature-born adults, suggesting an increased risk for accelerated brain aging in human prematurity.
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spelling pubmed-80470542021-04-16 Increased Brain Age Gap Estimate (BrainAGE) in Young Adults After Premature Birth Hedderich, Dennis M. Menegaux, Aurore Schmitz-Koep, Benita Nuttall, Rachel Zimmermann, Juliana Schneider, Sebastian C. Bäuml, Josef G. Daamen, Marcel Boecker, Henning Wilke, Marko Zimmer, Claus Wolke, Dieter Bartmann, Peter Sorg, Christian Gaser, Christian Front Aging Neurosci Neuroscience Recent evidence suggests increased metabolic and physiologic aging rates in premature-born adults. While the lasting consequences of premature birth on human brain development are known, its impact on brain aging remains unclear. We addressed the question of whether premature birth impacts brain age gap estimates (BrainAGE) using an accurate and robust machine-learning framework based on structural MRI in a large cohort of young premature-born adults (n = 101) and full-term (FT) controls (n = 111). Study participants are part of a geographically defined population study of premature-born individuals, which have been followed longitudinally from birth until young adulthood. We investigated the association between BrainAGE scores and perinatal variables as well as with outcomes of physical (total intracranial volume, TIV) and cognitive development (full-scale IQ, FS-IQ). We found increased BrainAGE in premature-born adults [median (interquartile range) = 1.4 (−1.3–4.7 years)] compared to full-term controls (p = 0.002, Cohen’s d = 0.443), which was associated with low Gestational age (GA), low birth weight (BW), and increased neonatal treatment intensity but not with TIV or FS-IQ. In conclusion, results demonstrate elevated BrainAGE in premature-born adults, suggesting an increased risk for accelerated brain aging in human prematurity. Frontiers Media S.A. 2021-04-01 /pmc/articles/PMC8047054/ /pubmed/33867970 http://dx.doi.org/10.3389/fnagi.2021.653365 Text en Copyright © 2021 Hedderich, Menegaux, Schmitz-Koep, Nuttall, Zimmermann, Schneider, Bäuml, Daamen, Boecker, Wilke, Zimmer, Wolke, Bartmann, Sorg and Gaser. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Hedderich, Dennis M.
Menegaux, Aurore
Schmitz-Koep, Benita
Nuttall, Rachel
Zimmermann, Juliana
Schneider, Sebastian C.
Bäuml, Josef G.
Daamen, Marcel
Boecker, Henning
Wilke, Marko
Zimmer, Claus
Wolke, Dieter
Bartmann, Peter
Sorg, Christian
Gaser, Christian
Increased Brain Age Gap Estimate (BrainAGE) in Young Adults After Premature Birth
title Increased Brain Age Gap Estimate (BrainAGE) in Young Adults After Premature Birth
title_full Increased Brain Age Gap Estimate (BrainAGE) in Young Adults After Premature Birth
title_fullStr Increased Brain Age Gap Estimate (BrainAGE) in Young Adults After Premature Birth
title_full_unstemmed Increased Brain Age Gap Estimate (BrainAGE) in Young Adults After Premature Birth
title_short Increased Brain Age Gap Estimate (BrainAGE) in Young Adults After Premature Birth
title_sort increased brain age gap estimate (brainage) in young adults after premature birth
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047054/
https://www.ncbi.nlm.nih.gov/pubmed/33867970
http://dx.doi.org/10.3389/fnagi.2021.653365
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