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Interplay Between Thiamine and p53/p21 Axes Affects Antiproliferative Action of Cisplatin in Lung Adenocarcinoma Cells by Changing Metabolism of 2-Oxoglutarate/Glutamate

Thiamine (vitamin B1) is often deficient in oncopatients, particularly those undergoing chemotherapy. However, interaction between the thiamine deficiency and anticancer action of drugs has not been characterized. A major natural thiamine derivative, thiamine diphosphate (ThDP), is a coenzyme of cen...

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Detalles Bibliográficos
Autores principales:	Aleshin, Vasily A., Zhou, Xiaoshan, Krishnan, Shuba, Karlsson, Anna, Bunik, Victoria I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047112/ https://www.ncbi.nlm.nih.gov/pubmed/33868388 http://dx.doi.org/10.3389/fgene.2021.658446

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