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Semaphorin Regulation by the Chromatin Remodeler CHD7: An Emerging Genetic Interaction Shaping Neural Cells and Neural Crest in Development and Cancer

CHD7 is a chromatin remodeler protein that controls gene expression via the formation of multi-protein complexes with specific transcription factors. During development, CHD7 controls several differentiation programs, mainly by acting on neural progenitors and neural crest (NC) cells. Thus, its role...

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Autores principales: Lettieri, Antonella, Oleari, Roberto, Paganoni, Alyssa J. J., Gervasini, Cristina, Massa, Valentina, Fantin, Alessandro, Cariboni, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047133/
https://www.ncbi.nlm.nih.gov/pubmed/33869187
http://dx.doi.org/10.3389/fcell.2021.638674
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author Lettieri, Antonella
Oleari, Roberto
Paganoni, Alyssa J. J.
Gervasini, Cristina
Massa, Valentina
Fantin, Alessandro
Cariboni, Anna
author_facet Lettieri, Antonella
Oleari, Roberto
Paganoni, Alyssa J. J.
Gervasini, Cristina
Massa, Valentina
Fantin, Alessandro
Cariboni, Anna
author_sort Lettieri, Antonella
collection PubMed
description CHD7 is a chromatin remodeler protein that controls gene expression via the formation of multi-protein complexes with specific transcription factors. During development, CHD7 controls several differentiation programs, mainly by acting on neural progenitors and neural crest (NC) cells. Thus, its roles range from the central nervous system to the peripheral nervous system and the organs colonized by NC cells, including the heart. Accordingly, mutated CHD7 is linked to CHARGE syndrome, which is characterized by several neuronal dysfunctions and by malformations of NC-derived/populated organs. Altered CHD7 has also been associated with different neoplastic transformations. Interestingly, recent evidence revealed that semaphorins, a class of molecules involved in developmental and pathological processes similar to those controlled by CHD7, are regulated by CHD7 in a context-specific manner. In this article, we will review the recent insights that support the existence of genetic interactions between these pathways, both during developmental processes and cancer progression.
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spelling pubmed-80471332021-04-16 Semaphorin Regulation by the Chromatin Remodeler CHD7: An Emerging Genetic Interaction Shaping Neural Cells and Neural Crest in Development and Cancer Lettieri, Antonella Oleari, Roberto Paganoni, Alyssa J. J. Gervasini, Cristina Massa, Valentina Fantin, Alessandro Cariboni, Anna Front Cell Dev Biol Cell and Developmental Biology CHD7 is a chromatin remodeler protein that controls gene expression via the formation of multi-protein complexes with specific transcription factors. During development, CHD7 controls several differentiation programs, mainly by acting on neural progenitors and neural crest (NC) cells. Thus, its roles range from the central nervous system to the peripheral nervous system and the organs colonized by NC cells, including the heart. Accordingly, mutated CHD7 is linked to CHARGE syndrome, which is characterized by several neuronal dysfunctions and by malformations of NC-derived/populated organs. Altered CHD7 has also been associated with different neoplastic transformations. Interestingly, recent evidence revealed that semaphorins, a class of molecules involved in developmental and pathological processes similar to those controlled by CHD7, are regulated by CHD7 in a context-specific manner. In this article, we will review the recent insights that support the existence of genetic interactions between these pathways, both during developmental processes and cancer progression. Frontiers Media S.A. 2021-04-01 /pmc/articles/PMC8047133/ /pubmed/33869187 http://dx.doi.org/10.3389/fcell.2021.638674 Text en Copyright © 2021 Lettieri, Oleari, Paganoni, Gervasini, Massa, Fantin and Cariboni. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Lettieri, Antonella
Oleari, Roberto
Paganoni, Alyssa J. J.
Gervasini, Cristina
Massa, Valentina
Fantin, Alessandro
Cariboni, Anna
Semaphorin Regulation by the Chromatin Remodeler CHD7: An Emerging Genetic Interaction Shaping Neural Cells and Neural Crest in Development and Cancer
title Semaphorin Regulation by the Chromatin Remodeler CHD7: An Emerging Genetic Interaction Shaping Neural Cells and Neural Crest in Development and Cancer
title_full Semaphorin Regulation by the Chromatin Remodeler CHD7: An Emerging Genetic Interaction Shaping Neural Cells and Neural Crest in Development and Cancer
title_fullStr Semaphorin Regulation by the Chromatin Remodeler CHD7: An Emerging Genetic Interaction Shaping Neural Cells and Neural Crest in Development and Cancer
title_full_unstemmed Semaphorin Regulation by the Chromatin Remodeler CHD7: An Emerging Genetic Interaction Shaping Neural Cells and Neural Crest in Development and Cancer
title_short Semaphorin Regulation by the Chromatin Remodeler CHD7: An Emerging Genetic Interaction Shaping Neural Cells and Neural Crest in Development and Cancer
title_sort semaphorin regulation by the chromatin remodeler chd7: an emerging genetic interaction shaping neural cells and neural crest in development and cancer
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047133/
https://www.ncbi.nlm.nih.gov/pubmed/33869187
http://dx.doi.org/10.3389/fcell.2021.638674
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