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Extracellular Vesicles in Tumors: A Potential Mediator of Bone Metastasis

As one of the most common metastatic sites, bone has a unique microenvironment for the growth and prosperity of metastatic tumor cells. Bone metastasis is a common complication for tumor patients and accounts for 15–20% of systemic metastasis, which is only secondary to lung and liver metastasis. Ca...

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Detalles Bibliográficos
Autores principales: Li, Shenglong, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047145/
https://www.ncbi.nlm.nih.gov/pubmed/33869189
http://dx.doi.org/10.3389/fcell.2021.639514
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author Li, Shenglong
Wang, Wei
author_facet Li, Shenglong
Wang, Wei
author_sort Li, Shenglong
collection PubMed
description As one of the most common metastatic sites, bone has a unique microenvironment for the growth and prosperity of metastatic tumor cells. Bone metastasis is a common complication for tumor patients and accounts for 15–20% of systemic metastasis, which is only secondary to lung and liver metastasis. Cancers prone to bone metastasis include lung, breast, and prostate cancer. Extracellular vesicles (EVs) are lipid membrane vesicles released from different cell types. It is clear that EVs are associated with multiple biological phenomena and are crucial for intracellular communication by transporting intracellular substances. Recent studies have implicated EVs in the development of cancer. However, the potential roles of EVs in the pathological exchange of bone cells between tumors and the bone microenvironment remain an emerging area. This review is focused on the role of tumor-derived EVs in bone metastasis and possible regulatory mechanisms.
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spelling pubmed-80471452021-04-16 Extracellular Vesicles in Tumors: A Potential Mediator of Bone Metastasis Li, Shenglong Wang, Wei Front Cell Dev Biol Cell and Developmental Biology As one of the most common metastatic sites, bone has a unique microenvironment for the growth and prosperity of metastatic tumor cells. Bone metastasis is a common complication for tumor patients and accounts for 15–20% of systemic metastasis, which is only secondary to lung and liver metastasis. Cancers prone to bone metastasis include lung, breast, and prostate cancer. Extracellular vesicles (EVs) are lipid membrane vesicles released from different cell types. It is clear that EVs are associated with multiple biological phenomena and are crucial for intracellular communication by transporting intracellular substances. Recent studies have implicated EVs in the development of cancer. However, the potential roles of EVs in the pathological exchange of bone cells between tumors and the bone microenvironment remain an emerging area. This review is focused on the role of tumor-derived EVs in bone metastasis and possible regulatory mechanisms. Frontiers Media S.A. 2021-04-01 /pmc/articles/PMC8047145/ /pubmed/33869189 http://dx.doi.org/10.3389/fcell.2021.639514 Text en Copyright © 2021 Li and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Li, Shenglong
Wang, Wei
Extracellular Vesicles in Tumors: A Potential Mediator of Bone Metastasis
title Extracellular Vesicles in Tumors: A Potential Mediator of Bone Metastasis
title_full Extracellular Vesicles in Tumors: A Potential Mediator of Bone Metastasis
title_fullStr Extracellular Vesicles in Tumors: A Potential Mediator of Bone Metastasis
title_full_unstemmed Extracellular Vesicles in Tumors: A Potential Mediator of Bone Metastasis
title_short Extracellular Vesicles in Tumors: A Potential Mediator of Bone Metastasis
title_sort extracellular vesicles in tumors: a potential mediator of bone metastasis
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047145/
https://www.ncbi.nlm.nih.gov/pubmed/33869189
http://dx.doi.org/10.3389/fcell.2021.639514
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