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Comparison of outcomes for percutaneous coronary intervention in men and women with unprotected left main disease

BACKGROUND: Percutaneous coronary intervention (PCI) in patients with unprotected left main coronary artery disease (ULMCAD) is increasing strategy in coronary artery patients. However, there is a lack of knowledge on the impact of sex on outcomes of patients undergoing ULMCAD PCI. METHODS: From Jan...

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Autores principales: LIU, Sheng-Wen, GUAN, Chang-Dong, HU, Feng-Huan, CHEN, Jue, DOU, Ke-Fei, YANG, Wei-Xian, WU, Yong-Jian, YANG, Yue-Jin, XU, Bo, QIAO, Shu-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047187/
https://www.ncbi.nlm.nih.gov/pubmed/33907546
http://dx.doi.org/10.11909/j.issn.1671-5411.2021.03.004
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author LIU, Sheng-Wen
GUAN, Chang-Dong
HU, Feng-Huan
CHEN, Jue
DOU, Ke-Fei
YANG, Wei-Xian
WU, Yong-Jian
YANG, Yue-Jin
XU, Bo
QIAO, Shu-Bin
author_facet LIU, Sheng-Wen
GUAN, Chang-Dong
HU, Feng-Huan
CHEN, Jue
DOU, Ke-Fei
YANG, Wei-Xian
WU, Yong-Jian
YANG, Yue-Jin
XU, Bo
QIAO, Shu-Bin
author_sort LIU, Sheng-Wen
collection PubMed
description BACKGROUND: Percutaneous coronary intervention (PCI) in patients with unprotected left main coronary artery disease (ULMCAD) is increasing strategy in coronary artery patients. However, there is a lack of knowledge on the impact of sex on outcomes of patients undergoing ULMCAD PCI. METHODS: From January 2004 to December 2015, there were 3,960 patients undergoing ULMCAD PCI at our institution, including 3,121 (78.8%) men and 839 (21.2%) women. The clinical outcome included the incidence of major adverse cardiac events (MACE) (the composite of all-cause death, myocardial infarction (MI), and revascularization), all-cause death, MI, revascularization at three years follow-up. RESULTS: Compared with men, women had not significantly different MACE (14.7% vs. 14.6%, P = 0.89, all-cause death (3.5% vs. 3.7%, P = 0.76), MI (5.0% vs. 4.3%, P = 0.38), revascularization (9.1% vs. 8.9%, P = 0.86), respectively. After adjustment, rates of MACE (HR = 1.49; 95% CI: 1.24−1.81;P < 0.0001) and all-cause death (HR = 1.65; 95% CI: 1.09−2.48; P = 0.017) occurred more frequently in male patients, as well as revascularization (HR = 1.46; 95% CI: 1.16−1.85;P = 0.001). CONCLUSION: In this analysis, compared to men, women undergoing ULMCAD PCI have better outcomes of MACE, all-cause death, and revascularization.
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spelling pubmed-80471872021-04-26 Comparison of outcomes for percutaneous coronary intervention in men and women with unprotected left main disease LIU, Sheng-Wen GUAN, Chang-Dong HU, Feng-Huan CHEN, Jue DOU, Ke-Fei YANG, Wei-Xian WU, Yong-Jian YANG, Yue-Jin XU, Bo QIAO, Shu-Bin J Geriatr Cardiol Research Article BACKGROUND: Percutaneous coronary intervention (PCI) in patients with unprotected left main coronary artery disease (ULMCAD) is increasing strategy in coronary artery patients. However, there is a lack of knowledge on the impact of sex on outcomes of patients undergoing ULMCAD PCI. METHODS: From January 2004 to December 2015, there were 3,960 patients undergoing ULMCAD PCI at our institution, including 3,121 (78.8%) men and 839 (21.2%) women. The clinical outcome included the incidence of major adverse cardiac events (MACE) (the composite of all-cause death, myocardial infarction (MI), and revascularization), all-cause death, MI, revascularization at three years follow-up. RESULTS: Compared with men, women had not significantly different MACE (14.7% vs. 14.6%, P = 0.89, all-cause death (3.5% vs. 3.7%, P = 0.76), MI (5.0% vs. 4.3%, P = 0.38), revascularization (9.1% vs. 8.9%, P = 0.86), respectively. After adjustment, rates of MACE (HR = 1.49; 95% CI: 1.24−1.81;P < 0.0001) and all-cause death (HR = 1.65; 95% CI: 1.09−2.48; P = 0.017) occurred more frequently in male patients, as well as revascularization (HR = 1.46; 95% CI: 1.16−1.85;P = 0.001). CONCLUSION: In this analysis, compared to men, women undergoing ULMCAD PCI have better outcomes of MACE, all-cause death, and revascularization. Science Press 2021-03-28 /pmc/articles/PMC8047187/ /pubmed/33907546 http://dx.doi.org/10.11909/j.issn.1671-5411.2021.03.004 Text en Copyright and License information: Journal of Geriatric Cardiology 2021 https://creativecommons.org/licenses/by-nc-sa/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ (https://creativecommons.org/licenses/by-nc-sa/4.0/)
spellingShingle Research Article
LIU, Sheng-Wen
GUAN, Chang-Dong
HU, Feng-Huan
CHEN, Jue
DOU, Ke-Fei
YANG, Wei-Xian
WU, Yong-Jian
YANG, Yue-Jin
XU, Bo
QIAO, Shu-Bin
Comparison of outcomes for percutaneous coronary intervention in men and women with unprotected left main disease
title Comparison of outcomes for percutaneous coronary intervention in men and women with unprotected left main disease
title_full Comparison of outcomes for percutaneous coronary intervention in men and women with unprotected left main disease
title_fullStr Comparison of outcomes for percutaneous coronary intervention in men and women with unprotected left main disease
title_full_unstemmed Comparison of outcomes for percutaneous coronary intervention in men and women with unprotected left main disease
title_short Comparison of outcomes for percutaneous coronary intervention in men and women with unprotected left main disease
title_sort comparison of outcomes for percutaneous coronary intervention in men and women with unprotected left main disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047187/
https://www.ncbi.nlm.nih.gov/pubmed/33907546
http://dx.doi.org/10.11909/j.issn.1671-5411.2021.03.004
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