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Hippo-Independent Regulation of Yki/Yap/Taz: A Non-canonical View
Initially identified in Drosophila, the Hippo signaling pathway has emerged as an evolutionarily conserved tumor suppressor pathway that controls tissue growth and organ size by simultaneously inhibiting cell proliferation and promoting cell death. Deregulation of Hippo pathway activity has been imp...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047194/ https://www.ncbi.nlm.nih.gov/pubmed/33869224 http://dx.doi.org/10.3389/fcell.2021.658481 |
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author | Cho, Yong Suk Jiang, Jin |
author_facet | Cho, Yong Suk Jiang, Jin |
author_sort | Cho, Yong Suk |
collection | PubMed |
description | Initially identified in Drosophila, the Hippo signaling pathway has emerged as an evolutionarily conserved tumor suppressor pathway that controls tissue growth and organ size by simultaneously inhibiting cell proliferation and promoting cell death. Deregulation of Hippo pathway activity has been implicated in a wide range of human cancers. The core Hippo pathway consists of a kinase cascade: an upstream kinase Hippo (Hpo)/MST1/2 phosphorylates and activates a downstream kinase Warts (Wts)/Lats1/2, leading to phosphorylation and inactivation of a transcriptional coactivator Yki/YAP/Taz. Many upstream signals, including cell adhesion, polarity, mechanical stress, and soluble factors, regulate Hippo signaling through the kinase cascade, leading to change in the cytoplasmic/nuclear localization of Yki/YAP/Taz. However, recent studies have uncovered other mechanisms that regulate Yki/YAP/Taz subcellular localization, stability, and activity independent of the Hpo kinase cascade. These mechanisms provide additional layers of pathway regulation, nodes for pathway crosstalk, and opportunities for pathway intervention in cancer treatment and regenerative medicine. |
format | Online Article Text |
id | pubmed-8047194 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80471942021-04-16 Hippo-Independent Regulation of Yki/Yap/Taz: A Non-canonical View Cho, Yong Suk Jiang, Jin Front Cell Dev Biol Cell and Developmental Biology Initially identified in Drosophila, the Hippo signaling pathway has emerged as an evolutionarily conserved tumor suppressor pathway that controls tissue growth and organ size by simultaneously inhibiting cell proliferation and promoting cell death. Deregulation of Hippo pathway activity has been implicated in a wide range of human cancers. The core Hippo pathway consists of a kinase cascade: an upstream kinase Hippo (Hpo)/MST1/2 phosphorylates and activates a downstream kinase Warts (Wts)/Lats1/2, leading to phosphorylation and inactivation of a transcriptional coactivator Yki/YAP/Taz. Many upstream signals, including cell adhesion, polarity, mechanical stress, and soluble factors, regulate Hippo signaling through the kinase cascade, leading to change in the cytoplasmic/nuclear localization of Yki/YAP/Taz. However, recent studies have uncovered other mechanisms that regulate Yki/YAP/Taz subcellular localization, stability, and activity independent of the Hpo kinase cascade. These mechanisms provide additional layers of pathway regulation, nodes for pathway crosstalk, and opportunities for pathway intervention in cancer treatment and regenerative medicine. Frontiers Media S.A. 2021-04-01 /pmc/articles/PMC8047194/ /pubmed/33869224 http://dx.doi.org/10.3389/fcell.2021.658481 Text en Copyright © 2021 Cho and Jiang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Cho, Yong Suk Jiang, Jin Hippo-Independent Regulation of Yki/Yap/Taz: A Non-canonical View |
title | Hippo-Independent Regulation of Yki/Yap/Taz: A Non-canonical View |
title_full | Hippo-Independent Regulation of Yki/Yap/Taz: A Non-canonical View |
title_fullStr | Hippo-Independent Regulation of Yki/Yap/Taz: A Non-canonical View |
title_full_unstemmed | Hippo-Independent Regulation of Yki/Yap/Taz: A Non-canonical View |
title_short | Hippo-Independent Regulation of Yki/Yap/Taz: A Non-canonical View |
title_sort | hippo-independent regulation of yki/yap/taz: a non-canonical view |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047194/ https://www.ncbi.nlm.nih.gov/pubmed/33869224 http://dx.doi.org/10.3389/fcell.2021.658481 |
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