Nkx2.5 Functions as a Conditional Tumor Suppressor Gene in Colorectal Cancer Cells via Acting as a Transcriptional Coactivator in p53-Mediated p21 Expression

NK2 homeobox 5 (Nkx2.5), a homeobox-containing transcription factor, is associated with a spectrum of congenital heart diseases. Recently, Nkx2.5 was also found to be differentially expressed in several kinds of tumors. In colorectal cancer (CRC) tissue and cells, hypermethylation of Nkx2.5 was obse...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Huili, Wang, Jiliang, Huang, Kun, Zhang, Tao, Gao, Lu, Yang, Sai, Yi, Wangyang, Niu, Yanfeng, Liu, Hongli, Wang, Zheng, Wang, Guobin, Tao, Kaixiong, Wang, Lin, Cai, Kailin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047315/
https://www.ncbi.nlm.nih.gov/pubmed/33869046
http://dx.doi.org/10.3389/fonc.2021.648045

Ejemplares similares

Ejemplares similares