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Exercise Training Preserves Myocardial Strain and Improves Exercise Tolerance in Doxorubicin-Induced Cardiotoxicity

Doxorubicin causes cardiotoxicity and exercise intolerance. Pre-conditioning exercise training seems to prevent doxorubicin-induced cardiac damage. However, the effectiveness of the cardioprotective effects of exercise training concomitantly with doxorubicin treatment remains largely unknown. To det...

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Autores principales: Gomes-Santos, Igor L., Jordão, Camila P., Passos, Clevia S., Brum, Patricia C., Oliveira, Edilamar M., Chammas, Roger, Camargo, Anamaria A., Negrão, Carlos E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047409/
https://www.ncbi.nlm.nih.gov/pubmed/33869297
http://dx.doi.org/10.3389/fcvm.2021.605993
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author Gomes-Santos, Igor L.
Jordão, Camila P.
Passos, Clevia S.
Brum, Patricia C.
Oliveira, Edilamar M.
Chammas, Roger
Camargo, Anamaria A.
Negrão, Carlos E.
author_facet Gomes-Santos, Igor L.
Jordão, Camila P.
Passos, Clevia S.
Brum, Patricia C.
Oliveira, Edilamar M.
Chammas, Roger
Camargo, Anamaria A.
Negrão, Carlos E.
author_sort Gomes-Santos, Igor L.
collection PubMed
description Doxorubicin causes cardiotoxicity and exercise intolerance. Pre-conditioning exercise training seems to prevent doxorubicin-induced cardiac damage. However, the effectiveness of the cardioprotective effects of exercise training concomitantly with doxorubicin treatment remains largely unknown. To determine whether low-to-moderate intensity aerobic exercise training during doxorubicin treatment would prevent cardiotoxicity and exercise intolerance, we performed exercise training concomitantly with chronic doxorubicin treatment in mice. Ventricular structure and function were accessed by echocardiography, exercise tolerance by maximal exercise test, and cardiac biology by histological and molecular techniques. Doxorubicin-induced cardiotoxicity, evidenced by impaired ventricular function, cardiac atrophy, and fibrosis. Exercise training did not preserve left ventricular ejection fraction or reduced fibrosis. However, exercise training preserved myocardial circumferential strain alleviated cardiac atrophy and restored cardiomyocyte cross-sectional area. On the other hand, exercise training exacerbated doxorubicin-induced body wasting without affecting survival. Finally, exercise training blunted doxorubicin-induced exercise intolerance. Exercise training performed during doxorubicin-based chemotherapy can be a valuable approach to attenuate cardiotoxicity.
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spelling pubmed-80474092021-04-16 Exercise Training Preserves Myocardial Strain and Improves Exercise Tolerance in Doxorubicin-Induced Cardiotoxicity Gomes-Santos, Igor L. Jordão, Camila P. Passos, Clevia S. Brum, Patricia C. Oliveira, Edilamar M. Chammas, Roger Camargo, Anamaria A. Negrão, Carlos E. Front Cardiovasc Med Cardiovascular Medicine Doxorubicin causes cardiotoxicity and exercise intolerance. Pre-conditioning exercise training seems to prevent doxorubicin-induced cardiac damage. However, the effectiveness of the cardioprotective effects of exercise training concomitantly with doxorubicin treatment remains largely unknown. To determine whether low-to-moderate intensity aerobic exercise training during doxorubicin treatment would prevent cardiotoxicity and exercise intolerance, we performed exercise training concomitantly with chronic doxorubicin treatment in mice. Ventricular structure and function were accessed by echocardiography, exercise tolerance by maximal exercise test, and cardiac biology by histological and molecular techniques. Doxorubicin-induced cardiotoxicity, evidenced by impaired ventricular function, cardiac atrophy, and fibrosis. Exercise training did not preserve left ventricular ejection fraction or reduced fibrosis. However, exercise training preserved myocardial circumferential strain alleviated cardiac atrophy and restored cardiomyocyte cross-sectional area. On the other hand, exercise training exacerbated doxorubicin-induced body wasting without affecting survival. Finally, exercise training blunted doxorubicin-induced exercise intolerance. Exercise training performed during doxorubicin-based chemotherapy can be a valuable approach to attenuate cardiotoxicity. Frontiers Media S.A. 2021-04-01 /pmc/articles/PMC8047409/ /pubmed/33869297 http://dx.doi.org/10.3389/fcvm.2021.605993 Text en Copyright © 2021 Gomes-Santos, Jordão, Passos, Brum, Oliveira, Chammas, Camargo and Negrão. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Gomes-Santos, Igor L.
Jordão, Camila P.
Passos, Clevia S.
Brum, Patricia C.
Oliveira, Edilamar M.
Chammas, Roger
Camargo, Anamaria A.
Negrão, Carlos E.
Exercise Training Preserves Myocardial Strain and Improves Exercise Tolerance in Doxorubicin-Induced Cardiotoxicity
title Exercise Training Preserves Myocardial Strain and Improves Exercise Tolerance in Doxorubicin-Induced Cardiotoxicity
title_full Exercise Training Preserves Myocardial Strain and Improves Exercise Tolerance in Doxorubicin-Induced Cardiotoxicity
title_fullStr Exercise Training Preserves Myocardial Strain and Improves Exercise Tolerance in Doxorubicin-Induced Cardiotoxicity
title_full_unstemmed Exercise Training Preserves Myocardial Strain and Improves Exercise Tolerance in Doxorubicin-Induced Cardiotoxicity
title_short Exercise Training Preserves Myocardial Strain and Improves Exercise Tolerance in Doxorubicin-Induced Cardiotoxicity
title_sort exercise training preserves myocardial strain and improves exercise tolerance in doxorubicin-induced cardiotoxicity
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047409/
https://www.ncbi.nlm.nih.gov/pubmed/33869297
http://dx.doi.org/10.3389/fcvm.2021.605993
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