A weakened interface in the P182L variant of HSP27 associated with severe Charcot‐Marie‐Tooth neuropathy causes aberrant binding to interacting proteins

HSP27 is a human molecular chaperone that forms large, dynamic oligomers and functions in many aspects of cellular homeostasis. Mutations in HSP27 cause Charcot‐Marie‐Tooth (CMT) disease, the most common inherited disorder of the peripheral nervous system. A particularly severe form of CMT disease i...

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Autores principales: Reid Alderson, T, Adriaenssens, Elias, Asselbergh, Bob, Pritišanac, Iva, Van Lent, Jonas, Gastall, Heidi Y, Wälti, Marielle A, Louis, John M, Timmerman, Vincent, Baldwin, Andrew J, LP Benesch, Justin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047445/
https://www.ncbi.nlm.nih.gov/pubmed/33644875
http://dx.doi.org/10.15252/embj.2019103811

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