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Plasmodium falciparum finds the winning combination
After 3 years of laboratory drug pressure in the presence of a picomolar inhibitor, the parasite Plasmodium falciparum developed a combination strategy of gene amplification and mutation to regain viability. The mutation observed led to a dysfunctional enzyme, but new research reveals the clever mec...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Society for Biochemistry and Molecular Biology
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047455/ https://www.ncbi.nlm.nih.gov/pubmed/34237898 http://dx.doi.org/10.1016/j.jbc.2021.100526 |
| Sumario: | After 3 years of laboratory drug pressure in the presence of a picomolar inhibitor, the parasite Plasmodium falciparum developed a combination strategy of gene amplification and mutation to regain viability. The mutation observed led to a dysfunctional enzyme, but new research reveals the clever mechanism behind its success. Not that we needed a reminder of nature’s creativity in the time of a pandemic. |
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