Plasmodium falciparum finds the winning combination

After 3 years of laboratory drug pressure in the presence of a picomolar inhibitor, the parasite Plasmodium falciparum developed a combination strategy of gene amplification and mutation to regain viability. The mutation observed led to a dysfunctional enzyme, but new research reveals the clever mec...

Descripción completa

Detalles Bibliográficos
Autor principal: Hengge, Alvan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Editors' Pick Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047455/
https://www.ncbi.nlm.nih.gov/pubmed/34237898
http://dx.doi.org/10.1016/j.jbc.2021.100526
_version_ 1783679042484961280
author Hengge, Alvan C.
author_facet Hengge, Alvan C.
author_sort Hengge, Alvan C.
collection PubMed
description After 3 years of laboratory drug pressure in the presence of a picomolar inhibitor, the parasite Plasmodium falciparum developed a combination strategy of gene amplification and mutation to regain viability. The mutation observed led to a dysfunctional enzyme, but new research reveals the clever mechanism behind its success. Not that we needed a reminder of nature’s creativity in the time of a pandemic.
format Online
Article
Text
id pubmed-8047455
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher American Society for Biochemistry and Molecular Biology
record_format MEDLINE/PubMed
spelling pubmed-80474552021-04-16 Plasmodium falciparum finds the winning combination Hengge, Alvan C. J Biol Chem Editors' Pick Highlight After 3 years of laboratory drug pressure in the presence of a picomolar inhibitor, the parasite Plasmodium falciparum developed a combination strategy of gene amplification and mutation to regain viability. The mutation observed led to a dysfunctional enzyme, but new research reveals the clever mechanism behind its success. Not that we needed a reminder of nature’s creativity in the time of a pandemic. American Society for Biochemistry and Molecular Biology 2021-04-01 /pmc/articles/PMC8047455/ /pubmed/34237898 http://dx.doi.org/10.1016/j.jbc.2021.100526 Text en © 2021 The Author https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Editors' Pick Highlight
Hengge, Alvan C.
Plasmodium falciparum finds the winning combination
title Plasmodium falciparum finds the winning combination
title_full Plasmodium falciparum finds the winning combination
title_fullStr Plasmodium falciparum finds the winning combination
title_full_unstemmed Plasmodium falciparum finds the winning combination
title_short Plasmodium falciparum finds the winning combination
title_sort plasmodium falciparum finds the winning combination
topic Editors' Pick Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047455/
https://www.ncbi.nlm.nih.gov/pubmed/34237898
http://dx.doi.org/10.1016/j.jbc.2021.100526
work_keys_str_mv AT henggealvanc plasmodiumfalciparumfindsthewinningcombination

Ejemplares similares