One Stone, Two Birds: The Roles of Tim-3 in Acute Myeloid Leukemia

T cell immunoglobulin and mucin protein 3 (Tim-3) is an immune checkpoint and plays a vital role in immune responses during acute myeloid leukemia (AML). Targeting Tim-3 kills two birds with one stone by balancing the immune system and eliminating leukemia stem cells (LSCs) in AML. These functions m...

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Autores principales: Wang, Zhiding, Chen, Jinghong, Wang, Mengzhen, Zhang, Linlin, Yu, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047468/
https://www.ncbi.nlm.nih.gov/pubmed/33868234
http://dx.doi.org/10.3389/fimmu.2021.618710
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author Wang, Zhiding
Chen, Jinghong
Wang, Mengzhen
Zhang, Linlin
Yu, Li
author_facet Wang, Zhiding
Chen, Jinghong
Wang, Mengzhen
Zhang, Linlin
Yu, Li
author_sort Wang, Zhiding
collection PubMed
description T cell immunoglobulin and mucin protein 3 (Tim-3) is an immune checkpoint and plays a vital role in immune responses during acute myeloid leukemia (AML). Targeting Tim-3 kills two birds with one stone by balancing the immune system and eliminating leukemia stem cells (LSCs) in AML. These functions make Tim-3 a potential target for curing AML. This review mainly discusses the roles of Tim-3 in the immune system in AML and as an AML LSC marker, which sheds new light on the role of Tim-3 in AML immunotherapy.
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spelling pubmed-80474682021-04-16 One Stone, Two Birds: The Roles of Tim-3 in Acute Myeloid Leukemia Wang, Zhiding Chen, Jinghong Wang, Mengzhen Zhang, Linlin Yu, Li Front Immunol Immunology T cell immunoglobulin and mucin protein 3 (Tim-3) is an immune checkpoint and plays a vital role in immune responses during acute myeloid leukemia (AML). Targeting Tim-3 kills two birds with one stone by balancing the immune system and eliminating leukemia stem cells (LSCs) in AML. These functions make Tim-3 a potential target for curing AML. This review mainly discusses the roles of Tim-3 in the immune system in AML and as an AML LSC marker, which sheds new light on the role of Tim-3 in AML immunotherapy. Frontiers Media S.A. 2021-04-01 /pmc/articles/PMC8047468/ /pubmed/33868234 http://dx.doi.org/10.3389/fimmu.2021.618710 Text en Copyright © 2021 Wang, Chen, Wang, Zhang and Yu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wang, Zhiding
Chen, Jinghong
Wang, Mengzhen
Zhang, Linlin
Yu, Li
One Stone, Two Birds: The Roles of Tim-3 in Acute Myeloid Leukemia
title One Stone, Two Birds: The Roles of Tim-3 in Acute Myeloid Leukemia
title_full One Stone, Two Birds: The Roles of Tim-3 in Acute Myeloid Leukemia
title_fullStr One Stone, Two Birds: The Roles of Tim-3 in Acute Myeloid Leukemia
title_full_unstemmed One Stone, Two Birds: The Roles of Tim-3 in Acute Myeloid Leukemia
title_short One Stone, Two Birds: The Roles of Tim-3 in Acute Myeloid Leukemia
title_sort one stone, two birds: the roles of tim-3 in acute myeloid leukemia
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047468/
https://www.ncbi.nlm.nih.gov/pubmed/33868234
http://dx.doi.org/10.3389/fimmu.2021.618710
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