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Association between a low dose of proton pump inhibitors and kidney function decline in elderly hypertensive patients: a retrospective observational study
OBJECTIVES: Proton pump inhibitors (PPIs) are widely used for acid suppression therapy. Recently, PPI use was reported to be associated with chronic kidney disease (CKD); however, whether a low dose of PPIs is associated with CKD remains unknown. METHODS: This retrospective observational study inclu...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047853/ https://www.ncbi.nlm.nih.gov/pubmed/33845606 http://dx.doi.org/10.1177/03000605211006653 |
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author | Wakabayashi, Tomohito Hosohata, Keiko Oyama, Saki Inada, Ayaka Niinomi, Iku Kambara, Hiroko Iida, Tatsuya Hasebe, Keiko Matsuoka, Hiroyuki Uchida, Mayako Kumagai, Etsuko |
author_facet | Wakabayashi, Tomohito Hosohata, Keiko Oyama, Saki Inada, Ayaka Niinomi, Iku Kambara, Hiroko Iida, Tatsuya Hasebe, Keiko Matsuoka, Hiroyuki Uchida, Mayako Kumagai, Etsuko |
author_sort | Wakabayashi, Tomohito |
collection | PubMed |
description | OBJECTIVES: Proton pump inhibitors (PPIs) are widely used for acid suppression therapy. Recently, PPI use was reported to be associated with chronic kidney disease (CKD); however, whether a low dose of PPIs is associated with CKD remains unknown. METHODS: This retrospective observational study included hypertensive patients who visited Kenwakai Hospital between 2017 and 2019. Renal parameters, such as the estimated glomerular filtration rate (eGFR) and serum creatinine (Scr), were extracted from medical records and compared between three years before treatment and the baseline. PPI use was assessed as cumulative exposure for three years. RESULTS: The study population included 152 patients (57.9% men; mean age, 74.5 years). Of those, 35.5% were PPI users (low dose, 17.1%; high dose, 18.4%). A significant decrease in eGFR and an increase in Scr were observed between three years before treatment and the baseline in the high-dose PPI group but not the non-use or low-dose PPI groups. CONCLUSIONS: Our results suggest that a low dose of PPIs may be safe in clinical settings, but further prospective studies are needed to clarify our findings. |
format | Online Article Text |
id | pubmed-8047853 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-80478532021-04-27 Association between a low dose of proton pump inhibitors and kidney function decline in elderly hypertensive patients: a retrospective observational study Wakabayashi, Tomohito Hosohata, Keiko Oyama, Saki Inada, Ayaka Niinomi, Iku Kambara, Hiroko Iida, Tatsuya Hasebe, Keiko Matsuoka, Hiroyuki Uchida, Mayako Kumagai, Etsuko J Int Med Res Retrospective Clinical Research Report OBJECTIVES: Proton pump inhibitors (PPIs) are widely used for acid suppression therapy. Recently, PPI use was reported to be associated with chronic kidney disease (CKD); however, whether a low dose of PPIs is associated with CKD remains unknown. METHODS: This retrospective observational study included hypertensive patients who visited Kenwakai Hospital between 2017 and 2019. Renal parameters, such as the estimated glomerular filtration rate (eGFR) and serum creatinine (Scr), were extracted from medical records and compared between three years before treatment and the baseline. PPI use was assessed as cumulative exposure for three years. RESULTS: The study population included 152 patients (57.9% men; mean age, 74.5 years). Of those, 35.5% were PPI users (low dose, 17.1%; high dose, 18.4%). A significant decrease in eGFR and an increase in Scr were observed between three years before treatment and the baseline in the high-dose PPI group but not the non-use or low-dose PPI groups. CONCLUSIONS: Our results suggest that a low dose of PPIs may be safe in clinical settings, but further prospective studies are needed to clarify our findings. SAGE Publications 2021-04-12 /pmc/articles/PMC8047853/ /pubmed/33845606 http://dx.doi.org/10.1177/03000605211006653 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Retrospective Clinical Research Report Wakabayashi, Tomohito Hosohata, Keiko Oyama, Saki Inada, Ayaka Niinomi, Iku Kambara, Hiroko Iida, Tatsuya Hasebe, Keiko Matsuoka, Hiroyuki Uchida, Mayako Kumagai, Etsuko Association between a low dose of proton pump inhibitors and kidney function decline in elderly hypertensive patients: a retrospective observational study |
title | Association between a low dose of proton pump inhibitors and kidney function decline in elderly hypertensive patients: a retrospective observational study |
title_full | Association between a low dose of proton pump inhibitors and kidney function decline in elderly hypertensive patients: a retrospective observational study |
title_fullStr | Association between a low dose of proton pump inhibitors and kidney function decline in elderly hypertensive patients: a retrospective observational study |
title_full_unstemmed | Association between a low dose of proton pump inhibitors and kidney function decline in elderly hypertensive patients: a retrospective observational study |
title_short | Association between a low dose of proton pump inhibitors and kidney function decline in elderly hypertensive patients: a retrospective observational study |
title_sort | association between a low dose of proton pump inhibitors and kidney function decline in elderly hypertensive patients: a retrospective observational study |
topic | Retrospective Clinical Research Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047853/ https://www.ncbi.nlm.nih.gov/pubmed/33845606 http://dx.doi.org/10.1177/03000605211006653 |
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