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Uterine contractions in rodent models and humans

Aberrant uterine contractions can lead to preterm birth and other labour complications and are a significant cause of maternal morbidity and mortality. To investigate the mechanisms underlying dysfunctional uterine contractions, researchers have used experimentally tractable small animal models. How...

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Detalles Bibliográficos
Autores principales: Malik, Manasi, Roh, Michelle, England, Sarah K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047897/
https://www.ncbi.nlm.nih.gov/pubmed/33337577
http://dx.doi.org/10.1111/apha.13607
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author Malik, Manasi
Roh, Michelle
England, Sarah K.
author_facet Malik, Manasi
Roh, Michelle
England, Sarah K.
author_sort Malik, Manasi
collection PubMed
description Aberrant uterine contractions can lead to preterm birth and other labour complications and are a significant cause of maternal morbidity and mortality. To investigate the mechanisms underlying dysfunctional uterine contractions, researchers have used experimentally tractable small animal models. However, biological differences between humans and rodents change how researchers select their animal model and interpret their results. Here, we provide a general review of studies of uterine excitation and contractions in mice, rats, guinea pigs, and humans, in an effort to introduce new researchers to the field and help in the design and interpretation of experiments in rodent models.
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spelling pubmed-80478972021-04-16 Uterine contractions in rodent models and humans Malik, Manasi Roh, Michelle England, Sarah K. Acta Physiol (Oxf) Review Articles Aberrant uterine contractions can lead to preterm birth and other labour complications and are a significant cause of maternal morbidity and mortality. To investigate the mechanisms underlying dysfunctional uterine contractions, researchers have used experimentally tractable small animal models. However, biological differences between humans and rodents change how researchers select their animal model and interpret their results. Here, we provide a general review of studies of uterine excitation and contractions in mice, rats, guinea pigs, and humans, in an effort to introduce new researchers to the field and help in the design and interpretation of experiments in rodent models. John Wiley and Sons Inc. 2021-01-07 2021-04 /pmc/articles/PMC8047897/ /pubmed/33337577 http://dx.doi.org/10.1111/apha.13607 Text en © 2020 The Authors. Acta Physiologica published by John Wiley & Sons Ltd on behalf of Scandinavian Physiological Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Review Articles
Malik, Manasi
Roh, Michelle
England, Sarah K.
Uterine contractions in rodent models and humans
title Uterine contractions in rodent models and humans
title_full Uterine contractions in rodent models and humans
title_fullStr Uterine contractions in rodent models and humans
title_full_unstemmed Uterine contractions in rodent models and humans
title_short Uterine contractions in rodent models and humans
title_sort uterine contractions in rodent models and humans
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047897/
https://www.ncbi.nlm.nih.gov/pubmed/33337577
http://dx.doi.org/10.1111/apha.13607
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