Glucose‐induced cAMP elevation in β‐cells involves amplification of constitutive and glucagon‐activated GLP‐1 receptor signalling

AIM: cAMP typically signals downstream of G(s)‐coupled receptors and regulates numerous cell functions. In β‐cells, cAMP amplifies Ca(2+)‐triggered exocytosis of insulin granules. Glucose‐induced insulin secretion is associated with Ca(2+)‐ and metabolism‐dependent increases of the sub‐plasma‐membra...

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Detalles Bibliográficos
Autores principales: Shuai, Hongyan, Xu, Yunjian, Ahooghalandari, Parvin, Tengholm, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Metabolism and Nutritional Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047901/
https://www.ncbi.nlm.nih.gov/pubmed/33369112
http://dx.doi.org/10.1111/apha.13611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047901/
https://www.ncbi.nlm.nih.gov/pubmed/33369112
http://dx.doi.org/10.1111/apha.13611

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