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Glucose‐induced cAMP elevation in β‐cells involves amplification of constitutive and glucagon‐activated GLP‐1 receptor signalling
AIM: cAMP typically signals downstream of G(s)‐coupled receptors and regulates numerous cell functions. In β‐cells, cAMP amplifies Ca(2+)‐triggered exocytosis of insulin granules. Glucose‐induced insulin secretion is associated with Ca(2+)‐ and metabolism‐dependent increases of the sub‐plasma‐membra...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047901/ https://www.ncbi.nlm.nih.gov/pubmed/33369112 http://dx.doi.org/10.1111/apha.13611 |