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Clinical outcome of kidney transplantation after bariatric surgery: A single‐center, retrospective cohort study

Patients with class II and III obesity and end‐stage renal disease are often ineligible for kidney transplantation (KTx) due to increased postoperative complications and technically challenging surgery. Bariatric surgery (BS) can be an effective solution for KTx candidates who are considered inopera...

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Autores principales: Outmani, Loubna, Kimenai, Hendrikus J. A. N., Roodnat, Joke I., Leeman, Marjolijn, Biter, Ulas L., Klaassen, René A., IJzermans, Jan N. M., Minnee, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047925/
https://www.ncbi.nlm.nih.gov/pubmed/33368652
http://dx.doi.org/10.1111/ctr.14208
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author Outmani, Loubna
Kimenai, Hendrikus J. A. N.
Roodnat, Joke I.
Leeman, Marjolijn
Biter, Ulas L.
Klaassen, René A.
IJzermans, Jan N. M.
Minnee, Robert C.
author_facet Outmani, Loubna
Kimenai, Hendrikus J. A. N.
Roodnat, Joke I.
Leeman, Marjolijn
Biter, Ulas L.
Klaassen, René A.
IJzermans, Jan N. M.
Minnee, Robert C.
author_sort Outmani, Loubna
collection PubMed
description Patients with class II and III obesity and end‐stage renal disease are often ineligible for kidney transplantation (KTx) due to increased postoperative complications and technically challenging surgery. Bariatric surgery (BS) can be an effective solution for KTx candidates who are considered inoperable. The aim of this study is to evaluate outcomes of KTx after BS and to compare the outcomes to obese recipients (BMI ≥ 35 kg/m(2)) without BS. This retrospective, single‐center study included patients who received KTx after BS between January 1994 and December 2018. The primary outcome was postoperative complications. The secondary outcomes were graft and patient survival. In total, 156 patients were included, of whom 23 underwent BS prior to KTx. There were no significant differences in postoperative complications. After a median follow‐up of 5.1 years, death‐censored graft survival, uncensored graft survival, and patient survival were similar to controls (log rank test p = .845, .659, and .704, respectively). Dialysis pre‐transplantation (Hazard Ratio (HR) 2.55; 95%CI 1.03–6.34, p = .043) and diabetes (HR 2.41; 95%CI 1.11–5.22, p = .027) were independent risk factors for all‐cause mortality. A kidney from a deceased donor was an independent risk factor for death‐censored graft loss (HR 1.98; 95%CI 1.04–3.79, p = .038). Patients who received a KTx after BS have similar outcomes as obese transplant recipients.
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spelling pubmed-80479252021-04-16 Clinical outcome of kidney transplantation after bariatric surgery: A single‐center, retrospective cohort study Outmani, Loubna Kimenai, Hendrikus J. A. N. Roodnat, Joke I. Leeman, Marjolijn Biter, Ulas L. Klaassen, René A. IJzermans, Jan N. M. Minnee, Robert C. Clin Transplant Original Articles Patients with class II and III obesity and end‐stage renal disease are often ineligible for kidney transplantation (KTx) due to increased postoperative complications and technically challenging surgery. Bariatric surgery (BS) can be an effective solution for KTx candidates who are considered inoperable. The aim of this study is to evaluate outcomes of KTx after BS and to compare the outcomes to obese recipients (BMI ≥ 35 kg/m(2)) without BS. This retrospective, single‐center study included patients who received KTx after BS between January 1994 and December 2018. The primary outcome was postoperative complications. The secondary outcomes were graft and patient survival. In total, 156 patients were included, of whom 23 underwent BS prior to KTx. There were no significant differences in postoperative complications. After a median follow‐up of 5.1 years, death‐censored graft survival, uncensored graft survival, and patient survival were similar to controls (log rank test p = .845, .659, and .704, respectively). Dialysis pre‐transplantation (Hazard Ratio (HR) 2.55; 95%CI 1.03–6.34, p = .043) and diabetes (HR 2.41; 95%CI 1.11–5.22, p = .027) were independent risk factors for all‐cause mortality. A kidney from a deceased donor was an independent risk factor for death‐censored graft loss (HR 1.98; 95%CI 1.04–3.79, p = .038). Patients who received a KTx after BS have similar outcomes as obese transplant recipients. John Wiley and Sons Inc. 2021-01-09 2021-03 /pmc/articles/PMC8047925/ /pubmed/33368652 http://dx.doi.org/10.1111/ctr.14208 Text en © 2021 The Authors. Clinical Transplantation published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Outmani, Loubna
Kimenai, Hendrikus J. A. N.
Roodnat, Joke I.
Leeman, Marjolijn
Biter, Ulas L.
Klaassen, René A.
IJzermans, Jan N. M.
Minnee, Robert C.
Clinical outcome of kidney transplantation after bariatric surgery: A single‐center, retrospective cohort study
title Clinical outcome of kidney transplantation after bariatric surgery: A single‐center, retrospective cohort study
title_full Clinical outcome of kidney transplantation after bariatric surgery: A single‐center, retrospective cohort study
title_fullStr Clinical outcome of kidney transplantation after bariatric surgery: A single‐center, retrospective cohort study
title_full_unstemmed Clinical outcome of kidney transplantation after bariatric surgery: A single‐center, retrospective cohort study
title_short Clinical outcome of kidney transplantation after bariatric surgery: A single‐center, retrospective cohort study
title_sort clinical outcome of kidney transplantation after bariatric surgery: a single‐center, retrospective cohort study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047925/
https://www.ncbi.nlm.nih.gov/pubmed/33368652
http://dx.doi.org/10.1111/ctr.14208
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