Breaching self-tolerance by targeting the gatekeeper

Loss-of-function mutations in DNaseL13, the enzyme that restricts the amount of microparticle-associated DNA, cause SLE in humans and mice. In this issue of JEM, Hartl et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20201138) uncover a reduction in plasma DNASE1L3 enzymatic activity due to th...

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Detalles Bibliográficos
Autores principales: Wan, Zurong, Pascual, Virginia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047933/
https://www.ncbi.nlm.nih.gov/pubmed/33847707
http://dx.doi.org/10.1084/jem.20210322
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author Wan, Zurong
Pascual, Virginia
author_facet Wan, Zurong
Pascual, Virginia
author_sort Wan, Zurong
collection PubMed
description Loss-of-function mutations in DNaseL13, the enzyme that restricts the amount of microparticle-associated DNA, cause SLE in humans and mice. In this issue of JEM, Hartl et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20201138) uncover a reduction in plasma DNASE1L3 enzymatic activity due to the presence of autoantibodies in patients with nonfamilial SLE.
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spelling pubmed-80479332021-11-03 Breaching self-tolerance by targeting the gatekeeper Wan, Zurong Pascual, Virginia J Exp Med Insights Loss-of-function mutations in DNaseL13, the enzyme that restricts the amount of microparticle-associated DNA, cause SLE in humans and mice. In this issue of JEM, Hartl et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20201138) uncover a reduction in plasma DNASE1L3 enzymatic activity due to the presence of autoantibodies in patients with nonfamilial SLE. Rockefeller University Press 2021-04-13 /pmc/articles/PMC8047933/ /pubmed/33847707 http://dx.doi.org/10.1084/jem.20210322 Text en © 2021 Wan and Pascual http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Wan, Zurong
Pascual, Virginia
Breaching self-tolerance by targeting the gatekeeper
title Breaching self-tolerance by targeting the gatekeeper
title_full Breaching self-tolerance by targeting the gatekeeper
title_fullStr Breaching self-tolerance by targeting the gatekeeper
title_full_unstemmed Breaching self-tolerance by targeting the gatekeeper
title_short Breaching self-tolerance by targeting the gatekeeper
title_sort breaching self-tolerance by targeting the gatekeeper
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047933/
https://www.ncbi.nlm.nih.gov/pubmed/33847707
http://dx.doi.org/10.1084/jem.20210322
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