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Clinicopathological parameters for predicting non-invasive follicular thyroid neoplasm with papillary features (NIFTP)

BACKGROUND: Criteria for the preoperative diagnosis of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) have not yet been confirmed. This study aimed to analyze differences in clinicopathological characteristics between follicular variant of papillary thyroid car...

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Autores principales: Jang, Eunju, Kim, Kwangsoon, Jung, Chan Kwon, Bae, Ja Seong, Kim, Jeong Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047967/
https://www.ncbi.nlm.nih.gov/pubmed/33912339
http://dx.doi.org/10.1177/20420188211000500
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author Jang, Eunju
Kim, Kwangsoon
Jung, Chan Kwon
Bae, Ja Seong
Kim, Jeong Soo
author_facet Jang, Eunju
Kim, Kwangsoon
Jung, Chan Kwon
Bae, Ja Seong
Kim, Jeong Soo
author_sort Jang, Eunju
collection PubMed
description BACKGROUND: Criteria for the preoperative diagnosis of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) have not yet been confirmed. This study aimed to analyze differences in clinicopathological characteristics between follicular variant of papillary thyroid carcinoma (FVPTC) subtypes to determine which parameters are relevant in differentiating NIFTP from other variants. METHODS: We retrospectively analyzed the records of 199 patients with a preoperative diagnosis of FVPTC who underwent thyroid surgery at Seoul St. Mary’s Hospital (Seoul, Korea) from 2011 to 2015. Clinicopathological features were analyzed retrospectively via a complete review of medical charts and pathology reports of patients. RESULTS: The NIFTP and invasive encapsulated FVPTC (EFVPTC) groups showed relatively benign features, with a majority of the patients categorized as Bethesda category III (25.8% and 25.6%, respectively) or IV (34.8% and 30.2%, respectively), while the infiltrative FVPTC group showed more malignant features, with more patients categorized as category V (28.6%) or VI (47.6%) (p < 0.001). BRAF(V600E) mutations were significantly less prevalent in the NIFTP group (0%) and invasive EFVPTC group (4.7%) compared with the infiltrative FVPTC group (34.9%) (p < 0.001). Multivariate analysis showed that absence of BRAF(V600E) mutation (OR 20.311, p = 0.004) and lymph node metastasis (odds ratio 10.237, p = 0.004) were significantly associated with NIFTP. CONCLUSION: Although Bethesda category was a statistically significant factor in distinguishing FVPTC subtypes, it was not effective in conclusively distinguishing NIFTP and invasive EFVPTC. Absence of BRAF(V600E) mutation and lymph node metastasis are important features in distinguishing NIFTP from other subtypes.
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spelling pubmed-80479672021-04-27 Clinicopathological parameters for predicting non-invasive follicular thyroid neoplasm with papillary features (NIFTP) Jang, Eunju Kim, Kwangsoon Jung, Chan Kwon Bae, Ja Seong Kim, Jeong Soo Ther Adv Endocrinol Metab New Perspectives in the Diagnosis and Treatment of Endocrine Cancer BACKGROUND: Criteria for the preoperative diagnosis of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) have not yet been confirmed. This study aimed to analyze differences in clinicopathological characteristics between follicular variant of papillary thyroid carcinoma (FVPTC) subtypes to determine which parameters are relevant in differentiating NIFTP from other variants. METHODS: We retrospectively analyzed the records of 199 patients with a preoperative diagnosis of FVPTC who underwent thyroid surgery at Seoul St. Mary’s Hospital (Seoul, Korea) from 2011 to 2015. Clinicopathological features were analyzed retrospectively via a complete review of medical charts and pathology reports of patients. RESULTS: The NIFTP and invasive encapsulated FVPTC (EFVPTC) groups showed relatively benign features, with a majority of the patients categorized as Bethesda category III (25.8% and 25.6%, respectively) or IV (34.8% and 30.2%, respectively), while the infiltrative FVPTC group showed more malignant features, with more patients categorized as category V (28.6%) or VI (47.6%) (p < 0.001). BRAF(V600E) mutations were significantly less prevalent in the NIFTP group (0%) and invasive EFVPTC group (4.7%) compared with the infiltrative FVPTC group (34.9%) (p < 0.001). Multivariate analysis showed that absence of BRAF(V600E) mutation (OR 20.311, p = 0.004) and lymph node metastasis (odds ratio 10.237, p = 0.004) were significantly associated with NIFTP. CONCLUSION: Although Bethesda category was a statistically significant factor in distinguishing FVPTC subtypes, it was not effective in conclusively distinguishing NIFTP and invasive EFVPTC. Absence of BRAF(V600E) mutation and lymph node metastasis are important features in distinguishing NIFTP from other subtypes. SAGE Publications 2021-04-12 /pmc/articles/PMC8047967/ /pubmed/33912339 http://dx.doi.org/10.1177/20420188211000500 Text en © The Author(s), 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle New Perspectives in the Diagnosis and Treatment of Endocrine Cancer
Jang, Eunju
Kim, Kwangsoon
Jung, Chan Kwon
Bae, Ja Seong
Kim, Jeong Soo
Clinicopathological parameters for predicting non-invasive follicular thyroid neoplasm with papillary features (NIFTP)
title Clinicopathological parameters for predicting non-invasive follicular thyroid neoplasm with papillary features (NIFTP)
title_full Clinicopathological parameters for predicting non-invasive follicular thyroid neoplasm with papillary features (NIFTP)
title_fullStr Clinicopathological parameters for predicting non-invasive follicular thyroid neoplasm with papillary features (NIFTP)
title_full_unstemmed Clinicopathological parameters for predicting non-invasive follicular thyroid neoplasm with papillary features (NIFTP)
title_short Clinicopathological parameters for predicting non-invasive follicular thyroid neoplasm with papillary features (NIFTP)
title_sort clinicopathological parameters for predicting non-invasive follicular thyroid neoplasm with papillary features (niftp)
topic New Perspectives in the Diagnosis and Treatment of Endocrine Cancer
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047967/
https://www.ncbi.nlm.nih.gov/pubmed/33912339
http://dx.doi.org/10.1177/20420188211000500
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