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Higher maternal BMI early in pregnancy is associated with overweight and obesity in young adult offspring in Thailand
BACKGROUND: Rates of overweight and obesity among women of reproductive age have been steadily increasing worldwide and in Thailand. There is mounting evidence that maternal obesity during pregnancy is associated with an increased risk of obesity and other adverse health outcomes in the offspring, b...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048216/ https://www.ncbi.nlm.nih.gov/pubmed/33853557 http://dx.doi.org/10.1186/s12889-021-10678-z |
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author | Ounjaijean, Sakaewan Wongthanee, Antika Kulprachakarn, Kanokwan Rerkasem, Amaraporn Pruenglampoo, Sakda Mangklabruks, Ampica Rerkasem, Kittipan Derraik, José G. B. |
author_facet | Ounjaijean, Sakaewan Wongthanee, Antika Kulprachakarn, Kanokwan Rerkasem, Amaraporn Pruenglampoo, Sakda Mangklabruks, Ampica Rerkasem, Kittipan Derraik, José G. B. |
author_sort | Ounjaijean, Sakaewan |
collection | PubMed |
description | BACKGROUND: Rates of overweight and obesity among women of reproductive age have been steadily increasing worldwide and in Thailand. There is mounting evidence that maternal obesity during pregnancy is associated with an increased risk of obesity and other adverse health outcomes in the offspring, but such data are lacking for Thailand. We examined the associations between maternal body mass index (BMI) and anthropometry (particularly the likelihood of obesity) and cardiometabolic parameters in young adult offspring. METHODS: This was a prospective follow-up study of a birth cohort in Chiang Mai (Thailand). Pregnant women carrying singletons were recruited at their first antenatal visit (< 24 weeks of gestation) and followed until delivery in 1989–1990. Participants were their young adult offspring followed up in 2010. Maternal BMI was recorded at the first antenatal visit. The offspring underwent clinical assessments, including anthropometry, lipid profile, insulin sensitivity (HOMA-IR), blood pressure, and carotid intima-media thickness. The primary outcome of interest was the likelihood of obesity in the offspring. RESULTS: We assessed 628 young adults (54% were females) at 20.6 ± 0.5 years of age (range 19.1–22.1 years). The young adult offspring of mothers with overweight/obesity was 14.1 kg (95%CI 9.7, 18.5; p < 0.0001) and 9.4 kg (95% CI 6.1, 12.8; p < 0.0001) heavier than those born to mothers with underweight or normal weight, respectively, and had BMI 3.46 kg/m(2) (95%CI 2.26, 4.67; p < 0.0001) and 5.27 kg/m(2) (95%CI 3.67, 8.68; p < 0.0001) greater, respectively. For every 1-kg/m(2) increase in maternal BMI, the adjusted odds ratio (aOR) of offspring obesity was 25% greater (95%CI 1.10, 1.42; p < 0.001). Thus, the aOR of obesity in offspring of mothers with overweight/obesity was 4.6 times greater (95%CI 1.86, 11.26; p < 0.001) and nearly 17-fold greater (95%CI 1.96, 146.4; p = 0.010) compared to young adults born to mothers with normal weight or underweight, respectively. There were no observed associations between maternal BMI status and offspring metabolism or blood pressure. DISCUSSION: Maternal overweight/obesity early in pregnancy was associated with increased BMI and greater odds of obesity in their young adult offspring in Thailand. These findings highlight the public health importance of fostering healthier lifestyle choices among women of reproductive age. |
format | Online Article Text |
id | pubmed-8048216 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-80482162021-04-15 Higher maternal BMI early in pregnancy is associated with overweight and obesity in young adult offspring in Thailand Ounjaijean, Sakaewan Wongthanee, Antika Kulprachakarn, Kanokwan Rerkasem, Amaraporn Pruenglampoo, Sakda Mangklabruks, Ampica Rerkasem, Kittipan Derraik, José G. B. BMC Public Health Research Article BACKGROUND: Rates of overweight and obesity among women of reproductive age have been steadily increasing worldwide and in Thailand. There is mounting evidence that maternal obesity during pregnancy is associated with an increased risk of obesity and other adverse health outcomes in the offspring, but such data are lacking for Thailand. We examined the associations between maternal body mass index (BMI) and anthropometry (particularly the likelihood of obesity) and cardiometabolic parameters in young adult offspring. METHODS: This was a prospective follow-up study of a birth cohort in Chiang Mai (Thailand). Pregnant women carrying singletons were recruited at their first antenatal visit (< 24 weeks of gestation) and followed until delivery in 1989–1990. Participants were their young adult offspring followed up in 2010. Maternal BMI was recorded at the first antenatal visit. The offspring underwent clinical assessments, including anthropometry, lipid profile, insulin sensitivity (HOMA-IR), blood pressure, and carotid intima-media thickness. The primary outcome of interest was the likelihood of obesity in the offspring. RESULTS: We assessed 628 young adults (54% were females) at 20.6 ± 0.5 years of age (range 19.1–22.1 years). The young adult offspring of mothers with overweight/obesity was 14.1 kg (95%CI 9.7, 18.5; p < 0.0001) and 9.4 kg (95% CI 6.1, 12.8; p < 0.0001) heavier than those born to mothers with underweight or normal weight, respectively, and had BMI 3.46 kg/m(2) (95%CI 2.26, 4.67; p < 0.0001) and 5.27 kg/m(2) (95%CI 3.67, 8.68; p < 0.0001) greater, respectively. For every 1-kg/m(2) increase in maternal BMI, the adjusted odds ratio (aOR) of offspring obesity was 25% greater (95%CI 1.10, 1.42; p < 0.001). Thus, the aOR of obesity in offspring of mothers with overweight/obesity was 4.6 times greater (95%CI 1.86, 11.26; p < 0.001) and nearly 17-fold greater (95%CI 1.96, 146.4; p = 0.010) compared to young adults born to mothers with normal weight or underweight, respectively. There were no observed associations between maternal BMI status and offspring metabolism or blood pressure. DISCUSSION: Maternal overweight/obesity early in pregnancy was associated with increased BMI and greater odds of obesity in their young adult offspring in Thailand. These findings highlight the public health importance of fostering healthier lifestyle choices among women of reproductive age. BioMed Central 2021-04-14 /pmc/articles/PMC8048216/ /pubmed/33853557 http://dx.doi.org/10.1186/s12889-021-10678-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Ounjaijean, Sakaewan Wongthanee, Antika Kulprachakarn, Kanokwan Rerkasem, Amaraporn Pruenglampoo, Sakda Mangklabruks, Ampica Rerkasem, Kittipan Derraik, José G. B. Higher maternal BMI early in pregnancy is associated with overweight and obesity in young adult offspring in Thailand |
title | Higher maternal BMI early in pregnancy is associated with overweight and obesity in young adult offspring in Thailand |
title_full | Higher maternal BMI early in pregnancy is associated with overweight and obesity in young adult offspring in Thailand |
title_fullStr | Higher maternal BMI early in pregnancy is associated with overweight and obesity in young adult offspring in Thailand |
title_full_unstemmed | Higher maternal BMI early in pregnancy is associated with overweight and obesity in young adult offspring in Thailand |
title_short | Higher maternal BMI early in pregnancy is associated with overweight and obesity in young adult offspring in Thailand |
title_sort | higher maternal bmi early in pregnancy is associated with overweight and obesity in young adult offspring in thailand |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048216/ https://www.ncbi.nlm.nih.gov/pubmed/33853557 http://dx.doi.org/10.1186/s12889-021-10678-z |
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