Hypoxic preconditioning induces epigenetic changes and modifies swine mesenchymal stem cell angiogenesis and senescence in experimental atherosclerotic renal artery stenosis

BACKGROUND: Atherosclerotic renal artery stenosis (ARAS) is a risk factor for ischemic and hypertensive kidney disease (HKD) for which autologous mesenchymal stem cell (MSC) appears to be a promising therapy. However, MSCs from ARAS patients exhibit impaired function, senescence, and DNA damage, pos...

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Detalles Bibliográficos
Autores principales: Isik, Busra, Thaler, Roman, Goksu, Busra B., Conley, Sabena M., Al-Khafaji, Hayder, Mohan, Arjunmohan, Afarideh, Mohsen, Abumoawad, Abdelrhman M., Zhu, Xiang Y., Krier, James D., Saadiq, Ishran M., Tang, Hui, Eirin, Alfonso, Hickson, LaTonya J., van Wijnen, Andre J., Textor, Stephen C., Lerman, Lilach O., Herrmann, Sandra M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048283/
https://www.ncbi.nlm.nih.gov/pubmed/33853680
http://dx.doi.org/10.1186/s13287-021-02310-z

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