Sustainable Access to 5‐Amino‐Oxazoles and Thiazoles via Calcium‐Catalyzed Elimination‐Cyclization with Isocyanides

Herein, we report a sustainable, modular, rapid and high‐yielding transformation to afford densely functionalized 5‐aminooxazoles and thiazoles. The reaction is tolerant to a wide range of functional groups and is typically complete in under 30 min. Furthermore, the described transformation is inher...

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Detalles Bibliográficos
Autores principales: Basson, Ashley J., McLaughlin, Mark G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048476/
https://www.ncbi.nlm.nih.gov/pubmed/33605021
http://dx.doi.org/10.1002/cssc.202100225
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author Basson, Ashley J.
McLaughlin, Mark G.
author_facet Basson, Ashley J.
McLaughlin, Mark G.
author_sort Basson, Ashley J.
collection PubMed
description Herein, we report a sustainable, modular, rapid and high‐yielding transformation to afford densely functionalized 5‐aminooxazoles and thiazoles. The reaction is tolerant to a wide range of functional groups and is typically complete in under 30 min. Furthermore, the described transformation is inherently green in relation to the catalyst and solvent choice as well as producing environmentally benign alcoholic by‐products.
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spelling pubmed-80484762021-04-16 Sustainable Access to 5‐Amino‐Oxazoles and Thiazoles via Calcium‐Catalyzed Elimination‐Cyclization with Isocyanides Basson, Ashley J. McLaughlin, Mark G. ChemSusChem Communications Herein, we report a sustainable, modular, rapid and high‐yielding transformation to afford densely functionalized 5‐aminooxazoles and thiazoles. The reaction is tolerant to a wide range of functional groups and is typically complete in under 30 min. Furthermore, the described transformation is inherently green in relation to the catalyst and solvent choice as well as producing environmentally benign alcoholic by‐products. John Wiley and Sons Inc. 2021-03-03 2021-04-09 /pmc/articles/PMC8048476/ /pubmed/33605021 http://dx.doi.org/10.1002/cssc.202100225 Text en © 2021 The Authors. ChemSusChem published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Basson, Ashley J.
McLaughlin, Mark G.
Sustainable Access to 5‐Amino‐Oxazoles and Thiazoles via Calcium‐Catalyzed Elimination‐Cyclization with Isocyanides
title Sustainable Access to 5‐Amino‐Oxazoles and Thiazoles via Calcium‐Catalyzed Elimination‐Cyclization with Isocyanides
title_full Sustainable Access to 5‐Amino‐Oxazoles and Thiazoles via Calcium‐Catalyzed Elimination‐Cyclization with Isocyanides
title_fullStr Sustainable Access to 5‐Amino‐Oxazoles and Thiazoles via Calcium‐Catalyzed Elimination‐Cyclization with Isocyanides
title_full_unstemmed Sustainable Access to 5‐Amino‐Oxazoles and Thiazoles via Calcium‐Catalyzed Elimination‐Cyclization with Isocyanides
title_short Sustainable Access to 5‐Amino‐Oxazoles and Thiazoles via Calcium‐Catalyzed Elimination‐Cyclization with Isocyanides
title_sort sustainable access to 5‐amino‐oxazoles and thiazoles via calcium‐catalyzed elimination‐cyclization with isocyanides
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048476/
https://www.ncbi.nlm.nih.gov/pubmed/33605021
http://dx.doi.org/10.1002/cssc.202100225
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AT mclaughlinmarkg sustainableaccessto5aminooxazolesandthiazolesviacalciumcatalyzedeliminationcyclizationwithisocyanides

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