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Dysbiosis of Gut Microbiota and Short‐Chain Fatty Acids in Acute Ischemic Stroke and the Subsequent Risk for Poor Functional Outcomes

BACKGROUND: The intestinal microbiota and its metabolites have been reported to play an important role in stroke. Gut microbiota–originating short‐chain fatty acids (SCFAs) modulate brain functions directly or indirectly through immune, endocrine, vagal, and other humoral pathways. However, relative...

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Autores principales: Tan, Chuhong, Wu, Qiheng, Wang, Huidi, Gao, Xuxuan, Xu, Ruoting, Cui, Ziming, Zhu, Jiajia, Zeng, Xiuli, Zhou, Hongwei, He, Yan, Yin, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048557/
https://www.ncbi.nlm.nih.gov/pubmed/32473086
http://dx.doi.org/10.1002/jpen.1861
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author Tan, Chuhong
Wu, Qiheng
Wang, Huidi
Gao, Xuxuan
Xu, Ruoting
Cui, Ziming
Zhu, Jiajia
Zeng, Xiuli
Zhou, Hongwei
He, Yan
Yin, Jia
author_facet Tan, Chuhong
Wu, Qiheng
Wang, Huidi
Gao, Xuxuan
Xu, Ruoting
Cui, Ziming
Zhu, Jiajia
Zeng, Xiuli
Zhou, Hongwei
He, Yan
Yin, Jia
author_sort Tan, Chuhong
collection PubMed
description BACKGROUND: The intestinal microbiota and its metabolites have been reported to play an important role in stroke. Gut microbiota–originating short‐chain fatty acids (SCFAs) modulate brain functions directly or indirectly through immune, endocrine, vagal, and other humoral pathways. However, relatively few investigations have evaluated the gut microbiome and SCFAs spectrum or their potential associations with stroke outcomes in acute ischemic stroke (AIS) patients with different stroke severities. METHODS: We used 16S rRNA gene sequencing and gas chromatography to compare the fecal microbial composition and SCFA spectrum between AIS patients (n = 140) and healthy controls (n = 92). Their associations with 90‐day poor functional outcomes were evaluated by logistic regression models. RESULTS: We found that the intestinal microbiota distinguished AIS patients from healthy controls. A lack of SCFAs‐producing bacteria and a low fecal SCFAs level defined dysbiosis in AIS patients, especially those with increased stroke severity. The SCFAs levels were negatively correlated with stroke severity and prognosis. Reduced SCFAs levels, especially acetate, were associated with an increased risk of 90‐day poor functional outcomes even after adjustments. CONCLUSIONS: Dysbiosis of SCFAs‐producing bacteria and SCFAs in AIS patients increased the subsequent risk for poor functional outcomes, indicating that SCFAs could be potential prognostic markers and therapeutic targets for stroke.
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spelling pubmed-80485572021-04-19 Dysbiosis of Gut Microbiota and Short‐Chain Fatty Acids in Acute Ischemic Stroke and the Subsequent Risk for Poor Functional Outcomes Tan, Chuhong Wu, Qiheng Wang, Huidi Gao, Xuxuan Xu, Ruoting Cui, Ziming Zhu, Jiajia Zeng, Xiuli Zhou, Hongwei He, Yan Yin, Jia JPEN J Parenter Enteral Nutr Original Communications BACKGROUND: The intestinal microbiota and its metabolites have been reported to play an important role in stroke. Gut microbiota–originating short‐chain fatty acids (SCFAs) modulate brain functions directly or indirectly through immune, endocrine, vagal, and other humoral pathways. However, relatively few investigations have evaluated the gut microbiome and SCFAs spectrum or their potential associations with stroke outcomes in acute ischemic stroke (AIS) patients with different stroke severities. METHODS: We used 16S rRNA gene sequencing and gas chromatography to compare the fecal microbial composition and SCFA spectrum between AIS patients (n = 140) and healthy controls (n = 92). Their associations with 90‐day poor functional outcomes were evaluated by logistic regression models. RESULTS: We found that the intestinal microbiota distinguished AIS patients from healthy controls. A lack of SCFAs‐producing bacteria and a low fecal SCFAs level defined dysbiosis in AIS patients, especially those with increased stroke severity. The SCFAs levels were negatively correlated with stroke severity and prognosis. Reduced SCFAs levels, especially acetate, were associated with an increased risk of 90‐day poor functional outcomes even after adjustments. CONCLUSIONS: Dysbiosis of SCFAs‐producing bacteria and SCFAs in AIS patients increased the subsequent risk for poor functional outcomes, indicating that SCFAs could be potential prognostic markers and therapeutic targets for stroke. John Wiley and Sons Inc. 2020-05-30 2021-03 /pmc/articles/PMC8048557/ /pubmed/32473086 http://dx.doi.org/10.1002/jpen.1861 Text en © 2020 The Authors. Journal of Parenteral and Enteral Nutrition published by Wiley Periodicals, Inc. on behalf of American Society for Parenteral and Enteral Nutrition. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Communications
Tan, Chuhong
Wu, Qiheng
Wang, Huidi
Gao, Xuxuan
Xu, Ruoting
Cui, Ziming
Zhu, Jiajia
Zeng, Xiuli
Zhou, Hongwei
He, Yan
Yin, Jia
Dysbiosis of Gut Microbiota and Short‐Chain Fatty Acids in Acute Ischemic Stroke and the Subsequent Risk for Poor Functional Outcomes
title Dysbiosis of Gut Microbiota and Short‐Chain Fatty Acids in Acute Ischemic Stroke and the Subsequent Risk for Poor Functional Outcomes
title_full Dysbiosis of Gut Microbiota and Short‐Chain Fatty Acids in Acute Ischemic Stroke and the Subsequent Risk for Poor Functional Outcomes
title_fullStr Dysbiosis of Gut Microbiota and Short‐Chain Fatty Acids in Acute Ischemic Stroke and the Subsequent Risk for Poor Functional Outcomes
title_full_unstemmed Dysbiosis of Gut Microbiota and Short‐Chain Fatty Acids in Acute Ischemic Stroke and the Subsequent Risk for Poor Functional Outcomes
title_short Dysbiosis of Gut Microbiota and Short‐Chain Fatty Acids in Acute Ischemic Stroke and the Subsequent Risk for Poor Functional Outcomes
title_sort dysbiosis of gut microbiota and short‐chain fatty acids in acute ischemic stroke and the subsequent risk for poor functional outcomes
topic Original Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048557/
https://www.ncbi.nlm.nih.gov/pubmed/32473086
http://dx.doi.org/10.1002/jpen.1861
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