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Assembly of Dynamic Supramolecular Polymers on a DNA Origami Platform
Biological processes rely on transient interactions that govern assembly of biomolecules into higher order, multi‐component systems. A synthetic platform for the dynamic assembly of multicomponent complexes would provide novel entries to study and modulate the assembly of artificial systems into hig...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048573/ https://www.ncbi.nlm.nih.gov/pubmed/33444471 http://dx.doi.org/10.1002/anie.202016244 |
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author | Schill, Jurgen Rosier, Bas J. H. M. Gumí Audenis, Berta Magdalena Estirado, Eva de Greef, Tom F. A. Brunsveld, Luc |
author_facet | Schill, Jurgen Rosier, Bas J. H. M. Gumí Audenis, Berta Magdalena Estirado, Eva de Greef, Tom F. A. Brunsveld, Luc |
author_sort | Schill, Jurgen |
collection | PubMed |
description | Biological processes rely on transient interactions that govern assembly of biomolecules into higher order, multi‐component systems. A synthetic platform for the dynamic assembly of multicomponent complexes would provide novel entries to study and modulate the assembly of artificial systems into higher order topologies. Here, we establish a hybrid DNA origami‐based approach as an assembly platform that enables dynamic templating of supramolecular architectures. It entails the site‐selective recruitment of supramolecular polymers to the platform with preservation of the intrinsic dynamics and reversibility of the assembly process. The composition of the supramolecular assembly on the platform can be tuned dynamically, allowing for monomer rearrangement and inclusion of molecular cargo. This work should aid the study of supramolecular structures in their native environment in real‐time and incites new strategies for controlled multicomponent self‐assembly of synthetic building blocks. |
format | Online Article Text |
id | pubmed-8048573 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80485732021-04-19 Assembly of Dynamic Supramolecular Polymers on a DNA Origami Platform Schill, Jurgen Rosier, Bas J. H. M. Gumí Audenis, Berta Magdalena Estirado, Eva de Greef, Tom F. A. Brunsveld, Luc Angew Chem Int Ed Engl Communications Biological processes rely on transient interactions that govern assembly of biomolecules into higher order, multi‐component systems. A synthetic platform for the dynamic assembly of multicomponent complexes would provide novel entries to study and modulate the assembly of artificial systems into higher order topologies. Here, we establish a hybrid DNA origami‐based approach as an assembly platform that enables dynamic templating of supramolecular architectures. It entails the site‐selective recruitment of supramolecular polymers to the platform with preservation of the intrinsic dynamics and reversibility of the assembly process. The composition of the supramolecular assembly on the platform can be tuned dynamically, allowing for monomer rearrangement and inclusion of molecular cargo. This work should aid the study of supramolecular structures in their native environment in real‐time and incites new strategies for controlled multicomponent self‐assembly of synthetic building blocks. John Wiley and Sons Inc. 2021-02-26 2021-03-29 /pmc/articles/PMC8048573/ /pubmed/33444471 http://dx.doi.org/10.1002/anie.202016244 Text en © 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Communications Schill, Jurgen Rosier, Bas J. H. M. Gumí Audenis, Berta Magdalena Estirado, Eva de Greef, Tom F. A. Brunsveld, Luc Assembly of Dynamic Supramolecular Polymers on a DNA Origami Platform |
title | Assembly of Dynamic Supramolecular Polymers on a DNA Origami Platform |
title_full | Assembly of Dynamic Supramolecular Polymers on a DNA Origami Platform |
title_fullStr | Assembly of Dynamic Supramolecular Polymers on a DNA Origami Platform |
title_full_unstemmed | Assembly of Dynamic Supramolecular Polymers on a DNA Origami Platform |
title_short | Assembly of Dynamic Supramolecular Polymers on a DNA Origami Platform |
title_sort | assembly of dynamic supramolecular polymers on a dna origami platform |
topic | Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048573/ https://www.ncbi.nlm.nih.gov/pubmed/33444471 http://dx.doi.org/10.1002/anie.202016244 |
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