Cargando…

Development of a (68)Ga‐labelled PET tracer for carbonic anhydrase IX‐overexpressed tumors using the artificial sweetener saccharin

In this study, we developed a saccharin (SAC)‐based radiopharmaceutical ((68)Ga‐NOTA‐SAC) and evaluated the possibility of its application as a PET tracer in the diagnosis of carbonic anhydrase IX (CA IX)‐overexpressed tumors. We did a water‐soluble tetrazolium assay and flow cytometry analysis to i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shin, Un chul, Choi, Jeong Su, Beak, Yeon Jae, Lee, Min woo, Kim, Hyung Soo, Choi, Dal Woong, Kim, Dong Gil, Kim, Suhng Wook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048693/ https://www.ncbi.nlm.nih.gov/pubmed/33119930 http://dx.doi.org/10.1002/jlcr.3893

Ejemplares similares

[(68)Ga]Ga-4HMSA a promising new PET tracer for imaging inflammation
por: Kahn Ali, Shigufa, et al.
Publicado: (2021)

Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms
por: D’Ascenzio, Melissa, et al.
Publicado: (2016)

Dynamic PET/CT with the Hepatobiliary Tracer [68Ga]Ga-Tmos-DAZA for Characterization of a Hepatic Tumor
por: Freesmeyer, Martin, et al.
Publicado: (2021)

Peptide-Based [(68)Ga]Ga Labeled PET Tracer for Tumor Imaging by Targeting Tumor-Associated Macrophages
por: Huang, Mingxing, et al.
Publicado: (2022)

(68)Ga-Galmydar: A PET imaging tracer for noninvasive detection of Doxorubicin-induced cardiotoxicity
por: Sivapackiam, Jothilingam, et al.
Publicado: (2019)

Optimized (68)Ga-Labeled Urea-Based PSMA-Targeted PET Tracers for Prostate Cancer
por: Wu, Yitian, et al.
Publicado: (2022)

Evaluating [(68)Ga]Ga-p14-032 as a Novel PET Tracer for Diagnosis Cerebral Amyloid Angiopathy
por: Zhang, Qihui, et al.
Publicado: (2021)

Synthesis, preclinical evaluation and radiation dosimetry of a dual targeting PET tracer [(68)Ga]Ga-FAPI-RGD
por: Zang, Jie, et al.
Publicado: (2022)

Scale down and optimized automated production of [68Ga]68Ga-DOTA-ECL1i PET tracer targeting CCR2 expression
por: Migliari, Silvia, et al.
Publicado: (2023)

A dual tracer (68)Ga-DOTANOC PET/CT and (18)F-FDG PET/CT pilot study for detection of cardiac sarcoidosis
por: Gormsen, Lars C., et al.
Publicado: (2016)

(68)Ga-Labeling: Laying the Foundation for an Anti-Radiolytic Formulation for NOTA-sdAb PET Tracers
por: Baudhuin, Henri, et al.
Publicado: (2021)

Dual targeting PET tracer [(68)Ga]Ga-FAPI-RGD in patients with lung neoplasms: a pilot exploratory study
por: Wang, Rongxi, et al.
Publicado: (2023)

Shortened Tracer Uptake Time in GA-68-DOTATOC-PET of Meningiomas Does Not Impair Diagnostic Accuracy and PET Volume Definition
por: Graef, Josefine, et al.
Publicado: (2020)

Novel Preclinical and Radiopharmaceutical Aspects of [(68)Ga]Ga-PSMA-HBED-CC: A New PET Tracer for Imaging of Prostate Cancer
por: Eder, Matthias, et al.
Publicado: (2014)

PET-Based Human Dosimetry of (68)Ga-NODAGA-Exendin-4, a Tracer for β-Cell Imaging
por: Boss, Marti, et al.
Publicado: (2020)

The (68)Ge/(68)Ga generator has high potential, but when can we use (68)Ga-labelled tracers in clinical routine?
por: Breeman, Wouter A. P., et al.
Publicado: (2007)

A Flexible Synthesis of (68)Ga-Labeled Carbonic Anhydrase IX (CAIX)-Targeted Molecules via CBT/1,2-Aminothiol Click Reaction
por: Chen, Kuo-Ting, et al.
Publicado: (2018)

Saccharin Sulfonamides as Inhibitors of Carbonic Anhydrases I, II, VII, XII, and XIII
por: Morkūnaitė, Vaida, et al.
Publicado: (2014)

Fully-automated production of [(68)Ga]Ga-PentixaFor on the module Modular Lab-PharmTracer
por: Spreckelmeyer, Sarah, et al.
Publicado: (2020)

Synergistic Effect of Saccharin and Caffeine on Antiproliferative Activity in Human Ovarian Carcinoma Ovcar-3 Cells
por: Lee, Sun Ju, et al.
Publicado: (2023)

Synthesis, radiolabeling, and evaluation of 68Ga-labeled aminoquinoxaline derivative as a potent PFKFB3-targeted PET tracer
por: Chen, Feng, et al.
Publicado: (2023)

Comparison of Tracer Kinetic Models for 68Ga-PSMA-11 PET in Intermediate Risk Primary Prostate Cancer Patients
por: Smith, Nathaniel J., et al.
Publicado: (2023)

[(68)Ga]Ga-DOTA-TOC: The First FDA-Approved (68)Ga-Radiopharmaceutical for PET Imaging
por: Hennrich, Ute, et al.
Publicado: (2020)

Pancreatic serous cystoadenoma (CSA) showing increased tracer uptake at 68-GaDOTA-peptide Positron Emission Tomography (68Ga-DOTA-peptide PET-CT): a case report
por: Nappo, Gennaro, et al.
Publicado: (2020)

Angiogenesis PET Tracer Uptake ((68)Ga-NODAGA-E[(cRGDyK)](2)) in Induced Myocardial Infarction in Minipigs
por: Rasmussen, Thomas, et al.
Publicado: (2016)

Utility of [(68)Ga]FAPI-04 and [(18)F]FDG dual-tracer PET/CT in the initial evaluation of gastric cancer
por: Miao, Ying, et al.
Publicado: (2022)

Saccharin
Publicado: (1889)

Saccharin
Publicado: (1890)

Saccharine
Publicado: (1889)

Saccharine
por: Dougall, John
Publicado: (1888)

Saccharine
Publicado: (1886)

Saccharine
Publicado: (1888)

Saccharin
Publicado: (1888)

Saccharine
Publicado: (1888)

[(68)Ga]Ga-PSMA-11: The First FDA-Approved (68)Ga-Radiopharmaceutical for PET Imaging of Prostate Cancer
por: Hennrich, Ute, et al.
Publicado: (2021)

A Note on the Use of Saccharin as a Sweetening Agent from the Point of View of Public Health
por: Gupta, B. M.
Publicado: (1935)

THERANOSTICS: From Molecular Imaging Using Ga-68 Labeled Tracers and PET/CT to Personalized Radionuclide Therapy - The Bad Berka Experience
por: Baum, Richard P., et al.
Publicado: (2012)

Dual Tracer PET Imaging (68Ga-DOTATATE and 18F-FDG) Features in Pulmonary Carcinoid: Correlation with Tumor Proliferation Index
por: Bhatkar, Dhiraj, et al.
Publicado: (2017)

Dual Tracer 68Ga-DOTATOC and 18F-FDG PET Improve Preoperative Evaluation of Aggressiveness in Resectable Pancreatic Neuroendocrine Neoplasms
por: Mapelli, Paola, et al.
Publicado: (2021)

Whole-body uptake classification and prostate cancer staging in (68)Ga-PSMA-11 PET/CT using dual-tracer learning
por: Capobianco, Nicolò, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ff8gt589ellgfv4fi6spep85u3