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Protective effect of Houttuynia cordata extract on propofol-induced injury of rat hippocampal neurons by regulating PI3K/Akt and Toll-like receptor 4/NF-κB signaling pathway
OBJECTIVE: This study was to detect the protective effects of Houttuynia cordata extract on the damage induced by propofol in hippocampal neuron of rats. METHODS: Propofol-induced neuron injury model and H. cordata extract administration were conducted. Immunofluorescence and immunoblot were conduct...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048724/ https://www.ncbi.nlm.nih.gov/pubmed/33850081 http://dx.doi.org/10.1097/WNR.0000000000001627 |
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author | Fang, Hao Yang, Zhen Yang, Liu |
author_facet | Fang, Hao Yang, Zhen Yang, Liu |
author_sort | Fang, Hao |
collection | PubMed |
description | OBJECTIVE: This study was to detect the protective effects of Houttuynia cordata extract on the damage induced by propofol in hippocampal neuron of rats. METHODS: Propofol-induced neuron injury model and H. cordata extract administration were conducted. Immunofluorescence and immunoblot were conducted for the effect of H. cordata extract on neuronal activity and inflammation were detected in this model. RESULTS: H. cordata extracts increased neuronal activity, and reduced propofol-induced neuronal inflammation levels. H. cordata extract also reduced propofol-induced neuronal apoptosis. Mechanically, we noticed H. cordata extract activated phosphoinositide 3-kinase/AKT pathway and suppressed Toll-like receptor 4/nuclear factor kappaB pathway, therefore protected propofol-induced injury of rat hippocampal neurons. CONCLUSION: Our findings provide references for anesthetic use in infants and young children. |
format | Online Article Text |
id | pubmed-8048724 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-80487242021-04-19 Protective effect of Houttuynia cordata extract on propofol-induced injury of rat hippocampal neurons by regulating PI3K/Akt and Toll-like receptor 4/NF-κB signaling pathway Fang, Hao Yang, Zhen Yang, Liu Neuroreport Degeneration and Repair OBJECTIVE: This study was to detect the protective effects of Houttuynia cordata extract on the damage induced by propofol in hippocampal neuron of rats. METHODS: Propofol-induced neuron injury model and H. cordata extract administration were conducted. Immunofluorescence and immunoblot were conducted for the effect of H. cordata extract on neuronal activity and inflammation were detected in this model. RESULTS: H. cordata extracts increased neuronal activity, and reduced propofol-induced neuronal inflammation levels. H. cordata extract also reduced propofol-induced neuronal apoptosis. Mechanically, we noticed H. cordata extract activated phosphoinositide 3-kinase/AKT pathway and suppressed Toll-like receptor 4/nuclear factor kappaB pathway, therefore protected propofol-induced injury of rat hippocampal neurons. CONCLUSION: Our findings provide references for anesthetic use in infants and young children. Lippincott Williams & Wilkins 2021-03-11 2021-05-05 /pmc/articles/PMC8048724/ /pubmed/33850081 http://dx.doi.org/10.1097/WNR.0000000000001627 Text en Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Degeneration and Repair Fang, Hao Yang, Zhen Yang, Liu Protective effect of Houttuynia cordata extract on propofol-induced injury of rat hippocampal neurons by regulating PI3K/Akt and Toll-like receptor 4/NF-κB signaling pathway |
title | Protective effect of Houttuynia cordata extract on propofol-induced injury of rat hippocampal neurons by regulating PI3K/Akt and Toll-like receptor 4/NF-κB signaling pathway |
title_full | Protective effect of Houttuynia cordata extract on propofol-induced injury of rat hippocampal neurons by regulating PI3K/Akt and Toll-like receptor 4/NF-κB signaling pathway |
title_fullStr | Protective effect of Houttuynia cordata extract on propofol-induced injury of rat hippocampal neurons by regulating PI3K/Akt and Toll-like receptor 4/NF-κB signaling pathway |
title_full_unstemmed | Protective effect of Houttuynia cordata extract on propofol-induced injury of rat hippocampal neurons by regulating PI3K/Akt and Toll-like receptor 4/NF-κB signaling pathway |
title_short | Protective effect of Houttuynia cordata extract on propofol-induced injury of rat hippocampal neurons by regulating PI3K/Akt and Toll-like receptor 4/NF-κB signaling pathway |
title_sort | protective effect of houttuynia cordata extract on propofol-induced injury of rat hippocampal neurons by regulating pi3k/akt and toll-like receptor 4/nf-κb signaling pathway |
topic | Degeneration and Repair |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048724/ https://www.ncbi.nlm.nih.gov/pubmed/33850081 http://dx.doi.org/10.1097/WNR.0000000000001627 |
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