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Acute Running and Coronary Heart Disease Risk Markers in Male Cigarette Smokers and Nonsmokers: A Randomized Crossover Trial

PURPOSE: Cigarette smoking is an independent risk factor for coronary heart disease and is associated with impaired postprandial metabolism. Acute exercise reduces postprandial lipemia and improves other coronary heart disease risk markers in nonsmokers. Less is known about responses in cigarette sm...

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Autores principales: ALOTAIBI, TAREQ F., THACKRAY, ALICE E., ROBERTS, MATTHEW J., ALANAZI, TURKI M., BISHOP, NICOLETTE C., WADLEY, ALEX J., KING, JAMES A., O’DONNELL, EMMA, STEINER, MICHAEL C., SINGH, SALLY J., STENSEL, DAVID J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048727/
https://www.ncbi.nlm.nih.gov/pubmed/33196606
http://dx.doi.org/10.1249/MSS.0000000000002560
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author ALOTAIBI, TAREQ F.
THACKRAY, ALICE E.
ROBERTS, MATTHEW J.
ALANAZI, TURKI M.
BISHOP, NICOLETTE C.
WADLEY, ALEX J.
KING, JAMES A.
O’DONNELL, EMMA
STEINER, MICHAEL C.
SINGH, SALLY J.
STENSEL, DAVID J.
author_facet ALOTAIBI, TAREQ F.
THACKRAY, ALICE E.
ROBERTS, MATTHEW J.
ALANAZI, TURKI M.
BISHOP, NICOLETTE C.
WADLEY, ALEX J.
KING, JAMES A.
O’DONNELL, EMMA
STEINER, MICHAEL C.
SINGH, SALLY J.
STENSEL, DAVID J.
author_sort ALOTAIBI, TAREQ F.
collection PubMed
description PURPOSE: Cigarette smoking is an independent risk factor for coronary heart disease and is associated with impaired postprandial metabolism. Acute exercise reduces postprandial lipemia and improves other coronary heart disease risk markers in nonsmokers. Less is known about responses in cigarette smokers. METHODS: Twelve male cigarette smokers (mean ± SD; age = 23 ± 4 yr, body mass index = 24.9 ± 3.0 kg·m(−2)) and 12 male nonsmokers (age = 24 ± 4 yr, body mass index = 24.1 ± 2.0 kg·m(−2)) completed two, 2-d conditions (control and exercise) in a randomized crossover design. On day 1, participants rested for 9 h (0800–1700) in both conditions except a 60-min treadmill run (65% ± 7% peak oxygen uptake, 2.87 ± 0.54 MJ) was completed between 6.5 and 7.5 h (1430–1530) in the exercise condition. On day 2 of both conditions, participants rested and consumed two high-fat meals over 8 h (0900–1700) during which 13 venous blood samples and nine resting arterial blood pressure measurements were collected. RESULTS: Smokers exhibited higher postprandial triacylglycerol and C-reactive protein than nonsmokers (main effect group effect size [Cohen’s d] ≥ 0.94, P ≤ 0.034). Previous day running reduced postprandial triacylglycerol, insulin, and systolic and diastolic blood pressure (main effect condition d ≥ 0.28, P ≤ 0.044) and elevated postprandial nonesterified fatty acid and C-reactive protein (main effect condition d ≥ 0.41, P ≤ 0.044). Group–condition interactions were not apparent for any outcome across the total postprandial period (0–8 h; all P ≥ 0.089), but the exercise-induced reduction in postprandial triacylglycerol in the early postprandial period (0–4 h) was greater in nonsmokers than smokers (−21%, d = 0.43, vs −5%, d = 0.16, respectively; group–condition interaction P = 0.061). CONCLUSIONS: Acute moderate-intensity running reduced postprandial triacylglycerol, insulin, and resting arterial blood pressure the day after exercise in male cigarette smokers and nonsmokers. These findings highlight the ability of acute exercise to augment the postprandial metabolic health of cigarette smokers and nonsmokers.
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spelling pubmed-80487272021-04-19 Acute Running and Coronary Heart Disease Risk Markers in Male Cigarette Smokers and Nonsmokers: A Randomized Crossover Trial ALOTAIBI, TAREQ F. THACKRAY, ALICE E. ROBERTS, MATTHEW J. ALANAZI, TURKI M. BISHOP, NICOLETTE C. WADLEY, ALEX J. KING, JAMES A. O’DONNELL, EMMA STEINER, MICHAEL C. SINGH, SALLY J. STENSEL, DAVID J. Med Sci Sports Exerc Applied Sciences PURPOSE: Cigarette smoking is an independent risk factor for coronary heart disease and is associated with impaired postprandial metabolism. Acute exercise reduces postprandial lipemia and improves other coronary heart disease risk markers in nonsmokers. Less is known about responses in cigarette smokers. METHODS: Twelve male cigarette smokers (mean ± SD; age = 23 ± 4 yr, body mass index = 24.9 ± 3.0 kg·m(−2)) and 12 male nonsmokers (age = 24 ± 4 yr, body mass index = 24.1 ± 2.0 kg·m(−2)) completed two, 2-d conditions (control and exercise) in a randomized crossover design. On day 1, participants rested for 9 h (0800–1700) in both conditions except a 60-min treadmill run (65% ± 7% peak oxygen uptake, 2.87 ± 0.54 MJ) was completed between 6.5 and 7.5 h (1430–1530) in the exercise condition. On day 2 of both conditions, participants rested and consumed two high-fat meals over 8 h (0900–1700) during which 13 venous blood samples and nine resting arterial blood pressure measurements were collected. RESULTS: Smokers exhibited higher postprandial triacylglycerol and C-reactive protein than nonsmokers (main effect group effect size [Cohen’s d] ≥ 0.94, P ≤ 0.034). Previous day running reduced postprandial triacylglycerol, insulin, and systolic and diastolic blood pressure (main effect condition d ≥ 0.28, P ≤ 0.044) and elevated postprandial nonesterified fatty acid and C-reactive protein (main effect condition d ≥ 0.41, P ≤ 0.044). Group–condition interactions were not apparent for any outcome across the total postprandial period (0–8 h; all P ≥ 0.089), but the exercise-induced reduction in postprandial triacylglycerol in the early postprandial period (0–4 h) was greater in nonsmokers than smokers (−21%, d = 0.43, vs −5%, d = 0.16, respectively; group–condition interaction P = 0.061). CONCLUSIONS: Acute moderate-intensity running reduced postprandial triacylglycerol, insulin, and resting arterial blood pressure the day after exercise in male cigarette smokers and nonsmokers. These findings highlight the ability of acute exercise to augment the postprandial metabolic health of cigarette smokers and nonsmokers. Lippincott Williams & Wilkins 2021-05 2020-11-16 /pmc/articles/PMC8048727/ /pubmed/33196606 http://dx.doi.org/10.1249/MSS.0000000000002560 Text en Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Sports Medicine. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Applied Sciences
ALOTAIBI, TAREQ F.
THACKRAY, ALICE E.
ROBERTS, MATTHEW J.
ALANAZI, TURKI M.
BISHOP, NICOLETTE C.
WADLEY, ALEX J.
KING, JAMES A.
O’DONNELL, EMMA
STEINER, MICHAEL C.
SINGH, SALLY J.
STENSEL, DAVID J.
Acute Running and Coronary Heart Disease Risk Markers in Male Cigarette Smokers and Nonsmokers: A Randomized Crossover Trial
title Acute Running and Coronary Heart Disease Risk Markers in Male Cigarette Smokers and Nonsmokers: A Randomized Crossover Trial
title_full Acute Running and Coronary Heart Disease Risk Markers in Male Cigarette Smokers and Nonsmokers: A Randomized Crossover Trial
title_fullStr Acute Running and Coronary Heart Disease Risk Markers in Male Cigarette Smokers and Nonsmokers: A Randomized Crossover Trial
title_full_unstemmed Acute Running and Coronary Heart Disease Risk Markers in Male Cigarette Smokers and Nonsmokers: A Randomized Crossover Trial
title_short Acute Running and Coronary Heart Disease Risk Markers in Male Cigarette Smokers and Nonsmokers: A Randomized Crossover Trial
title_sort acute running and coronary heart disease risk markers in male cigarette smokers and nonsmokers: a randomized crossover trial
topic Applied Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048727/
https://www.ncbi.nlm.nih.gov/pubmed/33196606
http://dx.doi.org/10.1249/MSS.0000000000002560
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