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Antibiotic exposure among young infants suffering from diarrhoea in Bangladesh
AIMS: Appropriate rehydration has always been significant in treating diarrhoeal diseases in children. Irrational antibiotic use among diarrhoeal children has remained a major public health concern. Information regarding antibiotic use in young infants suffering from diarrhoea is very limited and a...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons Australia, Ltd.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048795/ https://www.ncbi.nlm.nih.gov/pubmed/33107165 http://dx.doi.org/10.1111/jpc.15233 |
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author | Islam, Md Ridwan Nuzhat, Sharika Fahim, Shah Mohammad Palit, Parag Flannery, Robin L Kyle, David J Mahfuz, Mustafa Islam, M Munirul Sarker, Shafiqul Alam Ahmed, Tahmeed |
author_facet | Islam, Md Ridwan Nuzhat, Sharika Fahim, Shah Mohammad Palit, Parag Flannery, Robin L Kyle, David J Mahfuz, Mustafa Islam, M Munirul Sarker, Shafiqul Alam Ahmed, Tahmeed |
author_sort | Islam, Md Ridwan |
collection | PubMed |
description | AIMS: Appropriate rehydration has always been significant in treating diarrhoeal diseases in children. Irrational antibiotic use among diarrhoeal children has remained a major public health concern. Information regarding antibiotic use in young infants suffering from diarrhoea is very limited and a unique aspect of research. We aimed to investigate the prevalence of antibiotic use in the community among 2–6 months infants with diarrhoeal illnesses and having different nutritional status. METHODS: We investigated a total of 5279 infants aged 2–6 months at Dhaka hospital, International Centre for Diarrhoeal Disease Research, Bangladesh, between September 2018 and June 2019. Among them, 257 infants were suffering from severe acute malnutrition (SAM). History of taking antibiotics was ascertained by direct observation of a prescription by a physician, the bottle of antibiotic or asking the caregiver about the name of antibiotic or its price that is very close to the usual market price of an antibiotic. RESULTS: Overall, 52% of infants received antibiotics before hospital admission. Non‐SAM infants had higher odds of receiving antibiotics (adjusted odds ratio [aOR] = 1.52, 95% confidence interval: 1.18, 1.97, P value = 0.003) compared to infants with SAM and use of antibiotics increased with age (aOR = 1.11, 95% confidence interval: 1.06, 1.17, P value<0.001). Commonly used antibiotics were azithromycin (13.3%), ciprofloxacin (7.7%), erythromycin (7.7%) and metronidazole (2.6%). The proportion of receiving ciprofloxacin was significantly lower in infants with SAM compared to their non‐SAM counterparts (2.7% vs. 7.97%, P value = 0.004). CONCLUSIONS: The study underscores the excessive use of antibiotics among diarrhoeal infants, which is already a major public health concern in low‐ and middle‐income countries. |
format | Online Article Text |
id | pubmed-8048795 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley & Sons Australia, Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80487952021-04-20 Antibiotic exposure among young infants suffering from diarrhoea in Bangladesh Islam, Md Ridwan Nuzhat, Sharika Fahim, Shah Mohammad Palit, Parag Flannery, Robin L Kyle, David J Mahfuz, Mustafa Islam, M Munirul Sarker, Shafiqul Alam Ahmed, Tahmeed J Paediatr Child Health Original Articles AIMS: Appropriate rehydration has always been significant in treating diarrhoeal diseases in children. Irrational antibiotic use among diarrhoeal children has remained a major public health concern. Information regarding antibiotic use in young infants suffering from diarrhoea is very limited and a unique aspect of research. We aimed to investigate the prevalence of antibiotic use in the community among 2–6 months infants with diarrhoeal illnesses and having different nutritional status. METHODS: We investigated a total of 5279 infants aged 2–6 months at Dhaka hospital, International Centre for Diarrhoeal Disease Research, Bangladesh, between September 2018 and June 2019. Among them, 257 infants were suffering from severe acute malnutrition (SAM). History of taking antibiotics was ascertained by direct observation of a prescription by a physician, the bottle of antibiotic or asking the caregiver about the name of antibiotic or its price that is very close to the usual market price of an antibiotic. RESULTS: Overall, 52% of infants received antibiotics before hospital admission. Non‐SAM infants had higher odds of receiving antibiotics (adjusted odds ratio [aOR] = 1.52, 95% confidence interval: 1.18, 1.97, P value = 0.003) compared to infants with SAM and use of antibiotics increased with age (aOR = 1.11, 95% confidence interval: 1.06, 1.17, P value<0.001). Commonly used antibiotics were azithromycin (13.3%), ciprofloxacin (7.7%), erythromycin (7.7%) and metronidazole (2.6%). The proportion of receiving ciprofloxacin was significantly lower in infants with SAM compared to their non‐SAM counterparts (2.7% vs. 7.97%, P value = 0.004). CONCLUSIONS: The study underscores the excessive use of antibiotics among diarrhoeal infants, which is already a major public health concern in low‐ and middle‐income countries. John Wiley & Sons Australia, Ltd. 2020-10-27 2021-03 /pmc/articles/PMC8048795/ /pubmed/33107165 http://dx.doi.org/10.1111/jpc.15233 Text en © 2020 The Authors. Journal of Paediatrics and Child Health published by John Wiley & Sons Australia, Ltd on behalf of Paediatrics and Child Health Division (The Royal Australasian College of Physicians). https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Islam, Md Ridwan Nuzhat, Sharika Fahim, Shah Mohammad Palit, Parag Flannery, Robin L Kyle, David J Mahfuz, Mustafa Islam, M Munirul Sarker, Shafiqul Alam Ahmed, Tahmeed Antibiotic exposure among young infants suffering from diarrhoea in Bangladesh |
title | Antibiotic exposure among young infants suffering from diarrhoea in Bangladesh |
title_full | Antibiotic exposure among young infants suffering from diarrhoea in Bangladesh |
title_fullStr | Antibiotic exposure among young infants suffering from diarrhoea in Bangladesh |
title_full_unstemmed | Antibiotic exposure among young infants suffering from diarrhoea in Bangladesh |
title_short | Antibiotic exposure among young infants suffering from diarrhoea in Bangladesh |
title_sort | antibiotic exposure among young infants suffering from diarrhoea in bangladesh |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8048795/ https://www.ncbi.nlm.nih.gov/pubmed/33107165 http://dx.doi.org/10.1111/jpc.15233 |
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