Recent Advances in Enantioselective Desymmetrizations of Prochiral Oxetanes

Strain relief of oxetanes offers a plethora of opportunities for the synthesis of chiral alcohols and ethers. In this context, enantioselective desymmetrization has been identified as a powerful tool to construct molecular complexity and this has led to the development of elegant strategies on the b...

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Detalles Bibliográficos
Autores principales: Sandvoß, Alexander, Wiest, Johannes M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Minireviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049043/
https://www.ncbi.nlm.nih.gov/pubmed/33274788
http://dx.doi.org/10.1002/chem.202004923
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author Sandvoß, Alexander
Wiest, Johannes M.
author_facet Sandvoß, Alexander
Wiest, Johannes M.
author_sort Sandvoß, Alexander
collection PubMed
description Strain relief of oxetanes offers a plethora of opportunities for the synthesis of chiral alcohols and ethers. In this context, enantioselective desymmetrization has been identified as a powerful tool to construct molecular complexity and this has led to the development of elegant strategies on the basis of transition metal, Lewis acid, and Brønsted acid catalysis. This review highlights recent examples that harness the inherent reactivity of prochiral oxetanes and offers an outlook on the immense possibilities for synthetic application.
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spelling pubmed-80490432021-04-21 Recent Advances in Enantioselective Desymmetrizations of Prochiral Oxetanes Sandvoß, Alexander Wiest, Johannes M. Chemistry Minireviews Strain relief of oxetanes offers a plethora of opportunities for the synthesis of chiral alcohols and ethers. In this context, enantioselective desymmetrization has been identified as a powerful tool to construct molecular complexity and this has led to the development of elegant strategies on the basis of transition metal, Lewis acid, and Brønsted acid catalysis. This review highlights recent examples that harness the inherent reactivity of prochiral oxetanes and offers an outlook on the immense possibilities for synthetic application. John Wiley and Sons Inc. 2021-02-02 2021-04-01 /pmc/articles/PMC8049043/ /pubmed/33274788 http://dx.doi.org/10.1002/chem.202004923 Text en © 2020 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Minireviews
Sandvoß, Alexander
Wiest, Johannes M.
Recent Advances in Enantioselective Desymmetrizations of Prochiral Oxetanes
title Recent Advances in Enantioselective Desymmetrizations of Prochiral Oxetanes
title_full Recent Advances in Enantioselective Desymmetrizations of Prochiral Oxetanes
title_fullStr Recent Advances in Enantioselective Desymmetrizations of Prochiral Oxetanes
title_full_unstemmed Recent Advances in Enantioselective Desymmetrizations of Prochiral Oxetanes
title_short Recent Advances in Enantioselective Desymmetrizations of Prochiral Oxetanes
title_sort recent advances in enantioselective desymmetrizations of prochiral oxetanes
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049043/
https://www.ncbi.nlm.nih.gov/pubmed/33274788
http://dx.doi.org/10.1002/chem.202004923
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