Fungal Dioxygenase AsqJ Is Promiscuous and Bimodal: Substrate‐Directed Formation of Quinolones versus Quinazolinones

Previous studies showed that the Fe(II)/α‐ketoglutarate dependent dioxygenase AsqJ induces a skeletal rearrangement in viridicatin biosynthesis in Aspergillus nidulans, generating a quinolone scaffold from benzo[1,4]diazepine‐2,5‐dione substrates. We report that AsqJ catalyzes an additional, entirel...

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Detalles Bibliográficos
Autores principales: Einsiedler, Manuel, Jamieson, Cooper S., Maskeri, Mark A., Houk, Kendall N., Gulder, Tobias A. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049060/
https://www.ncbi.nlm.nih.gov/pubmed/33411393
http://dx.doi.org/10.1002/anie.202017086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049060/
https://www.ncbi.nlm.nih.gov/pubmed/33411393
http://dx.doi.org/10.1002/anie.202017086

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