Cargando…

Fungal Dioxygenase AsqJ Is Promiscuous and Bimodal: Substrate‐Directed Formation of Quinolones versus Quinazolinones

Previous studies showed that the Fe(II)/α‐ketoglutarate dependent dioxygenase AsqJ induces a skeletal rearrangement in viridicatin biosynthesis in Aspergillus nidulans, generating a quinolone scaffold from benzo[1,4]diazepine‐2,5‐dione substrates. We report that AsqJ catalyzes an additional, entirel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Einsiedler, Manuel, Jamieson, Cooper S., Maskeri, Mark A., Houk, Kendall N., Gulder, Tobias A. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049060/ https://www.ncbi.nlm.nih.gov/pubmed/33411393 http://dx.doi.org/10.1002/anie.202017086

Ejemplares similares

Discovery of extended product structural space of the fungal dioxygenase AsqJ
por: Einsiedler, Manuel, et al.
Publicado: (2023)

Catalytic mechanism and molecular engineering of quinolone biosynthesis in dioxygenase AsqJ
por: Mader, Sophie L., et al.
Publicado: (2018)

On how the binding cavity of AsqJ dioxygenase controls the desaturation reaction regioselectivity: a QM/MM study
por: Wojdyla, Zuzanna, et al.
Publicado: (2018)

The ASQ CSQP study guide
por: Durivage, Mark
Publicado: (2018)

The ASQ CQE study guide
por: Borror, Connie M, et al.
Publicado: (2015)

The ASQ CSSGB study guide
por: Munro, Rodrick A, et al.
Publicado: (2017)

Discovery of N-quinazolinone-4-hydroxy-2-quinolone-3-carboxamides as DNA gyrase B-targeted antibacterial agents
por: Xue, Wenjie, et al.
Publicado: (2022)

Anxiety Symptoms Questionnaire (ASQ): development and validation
por: Baker, Amanda, et al.
Publicado: (2019)

Enzymatic one-step ring contraction for quinolone biosynthesis
por: Kishimoto, Shinji, et al.
Publicado: (2018)

ASQ pocket guide for the certified six sigma black belt
por: Kubiak, TM
Publicado: (2014)

Psychometric properties of the Chinese version of the Amblyopia and Strabismus Questionnaire (ASQE)
por: Bian, Wei, et al.
Publicado: (2015)

ASQ3 and/or the Bayley-III to support clinicians' decision making
por: Mackin, Robin, et al.
Publicado: (2017)

Reliability and Validity of the Korean Version of the Ask Suicide-Screening Questions (ASQ)
por: Kim, Hyun-Jin, et al.
Publicado: (2023)

Diagnostic accuracy of ASQ for screening of neurodevelopmental delays in low resource countries
por: Manasyan, Albert, et al.
Publicado: (2023)

Quality in the 21st century: perspectives from ASQ Feigenbaum medal winners
por: Sampaio, Paulo, et al.
Publicado: (2016)

BioASQ-QA: A manually curated corpus for Biomedical Question Answering
por: Krithara, Anastasia, et al.
Publicado: (2023)

Stabilizing AqdC, a Pseudomonas Quinolone Signal‐Cleaving Dioxygenase from Mycobacteria, by FRESCO‐Based Protein Engineering
por: Wullich, Sandra C., et al.
Publicado: (2020)

Iridium-catalysed direct sulfamidation of quinazolinones
por: Feng, Yadong, et al.
Publicado: (2018)

Quinazolinones, the Winning Horse in Drug Discovery
por: Alsibaee, Aishah M., et al.
Publicado: (2023)

NRPS Substrate Promiscuity Diversifies the Xenematides
por: Crawford, Jason M., et al.
Publicado: (2011)

Cross-Cultural Adaptation, Validation and Standardization of Ages and Stages Questionnaire (ASQ) in Iranian Children
por: VAMEGHI, Roshanak, et al.
Publicado: (2013)

Usefulness of Parent-Completed ASQ for Neurodevelopmental Screening of Preterm Children at Five Years of Age
por: Halbwachs, Marie, et al.
Publicado: (2013)

Comparison of Acoustic Structure Quantification (ASQ), shearwave elastography and histology in patients with diffuse hepatopathies
por: Keller, Jan, et al.
Publicado: (2015)

Multidimensional Aspects of de qi Sensations in MASS and ASQ Assessment: A Pilot Study
por: Jang, Jong-Chan, et al.
Publicado: (2017)

BioASQ at CLEF2020: Large-Scale Biomedical Semantic Indexing and Question Answering
por: Krallinger, Martin, et al.
Publicado: (2020)

Enzyme-Mediated Quenching of the Pseudomonas Quinolone Signal (PQS): A Comparison between Naturally Occurring and Engineered PQS-Cleaving Dioxygenases
por: Arranz San Martín, Alba, et al.
Publicado: (2022)

Uses of 2-Ethoxy-4(3H) quinazolinone in Synthesis of Quinazoline and Quinazolinone Derivatives of Antimicrobial Activity: The Solvent Effect
por: El-Hashash, Maher A., et al.
Publicado: (2012)

Enzyme-Catalyzed Cationic Epoxide Rearrangements in Quinolone Alkaloid Biosynthesis
por: Zou, Yi, et al.
Publicado: (2017)

Microwave-Assisted Synthesis of Quinazolines and Quinazolinones: An Overview
por: Mohammadkhani, Leyla, et al.
Publicado: (2020)

Preparation of quinazolinones using biosynthesized silver nanoparticles
por: Safaei-Ghomi, Javad, et al.
Publicado: (2022)

Recent advances and prospects in the organocatalytic synthesis of quinazolinones
por: Borah, Biplob, et al.
Publicado: (2022)

Effect of Baby Walker Use on Developmental Status based on Ages and Stages Questionnaire Score (ASQ)
por: YAGHINI, Omid, et al.
Publicado: (2020)

ASQ-3 and BSID-III’s concurrent validity and predictive ability of cognitive outcome at 5 years
por: Duggan, Cian, et al.
Publicado: (2023)

Substrate Promiscuity of N-Acetylhexosamine 1-Kinases
por: Li, Yanhong, et al.
Publicado: (2011)

A promiscuous cytochrome P450 aromatic O-demethylase for lignin bioconversion
por: Mallinson, Sam J. B., et al.
Publicado: (2018)

The Comparison of M-B CDI-K Short Form and K-ASQ as Screening Test for Language Development
por: Kim, Seong Woo, et al.
Publicado: (2016)

The shortened version of the Adolescent Stress Questionnaire (ASQ-S; Sweden): a validation study in United Kingdom adolescents
por: McKay, Michael, et al.
Publicado: (2019)

An Exploratory Analysis of the Internal Structure of Test Through a Multimethods Exploratory Approach of the ASQ:SE in Brazil
por: Anunciação, Luis, et al.
Publicado: (2022)

Amplicon Sequencing Minimal Information (ASqMI): Quality and Reporting Guidelines for Actionable Calls in Biodefense Applications
por: Keenum, Ishi, et al.
Publicado: (2023)

Synthesis and anticancer activity of novel quinazolinone-based rhodanines
por: El-Sayed, Sherihan, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_rnh7e5t5ikg1t062obml0gmkjt