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Transient “rest” restores functionality in exhausted CAR-T cells via epigenetic remodeling

T cell exhaustion limits immune responses against cancer and is a major cause of resistance to chimeric antigen receptor (CAR) T cell therapeutics. Using xenograft models and an in vitro model wherein tonic CAR signaling induces hallmark features of exhaustion, we tested the impact of transient cess...

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Detalles Bibliográficos
Autores principales:	Weber, Evan W., Parker, Kevin R., Sotillo, Elena, Lynn, Rachel C., Anbunathan, Hima, Lattin, John, Good, Zinaida, Belk, Julia A., Daniel, Bence, Klysz, Dorota, Malipatlolla, Meena, Xu, Peng, Bashti, Malek, Heitzeneder, Sabine, Labanieh, Louai, Vandris, Panayiotis, Majzner, Robbie G., Qi, Yanyan, Sandor, Katalin, Chen, Ling-Chun, Prabhu, Snehit, Gentles, Andrew J., Wandless, Thomas J., Satpathy, Ansuman T., Chang, Howard Y., Mackall, Crystal L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049103/ https://www.ncbi.nlm.nih.gov/pubmed/33795428 http://dx.doi.org/10.1126/science.aba1786

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