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Stratified Management for Bacterial Infections in Late Preterm and Term Neonates: Current Strategies and Future Opportunities Toward Precision Medicine
Bacterial infections remain a major cause of morbidity and mortality in the neonatal period. Therefore, many neonates, including late preterm and term neonates, are exposed to antibiotics in the first weeks of life. Data on the importance of inter-individual differences and disease signatures are ac...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049115/ https://www.ncbi.nlm.nih.gov/pubmed/33869108 http://dx.doi.org/10.3389/fped.2021.590969 |
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author | Keij, Fleur M. Achten, Niek B. Tramper-Stranders, Gerdien A. Allegaert, Karel van Rossum, Annemarie M. C. Reiss, Irwin K. M. Kornelisse, René F. |
author_facet | Keij, Fleur M. Achten, Niek B. Tramper-Stranders, Gerdien A. Allegaert, Karel van Rossum, Annemarie M. C. Reiss, Irwin K. M. Kornelisse, René F. |
author_sort | Keij, Fleur M. |
collection | PubMed |
description | Bacterial infections remain a major cause of morbidity and mortality in the neonatal period. Therefore, many neonates, including late preterm and term neonates, are exposed to antibiotics in the first weeks of life. Data on the importance of inter-individual differences and disease signatures are accumulating. Differences that may potentially influence treatment requirement and success rate. However, currently, many neonates are treated following a “one size fits all” approach, based on general protocols and standard antibiotic treatment regimens. Precision medicine has emerged in the last years and is perceived as a new, holistic, way of stratifying patients based on large-scale data including patient characteristics and disease specific features. Specific to sepsis, differences in disease susceptibility, disease severity, immune response and pharmacokinetics and -dynamics can be used for the development of treatment algorithms helping clinicians decide when and how to treat a specific patient or a specific subpopulation. In this review, we highlight the current and future developments that could allow transition to a more precise manner of antibiotic treatment in late preterm and term neonates, and propose a research agenda toward precision medicine for neonatal bacterial infections. |
format | Online Article Text |
id | pubmed-8049115 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80491152021-04-16 Stratified Management for Bacterial Infections in Late Preterm and Term Neonates: Current Strategies and Future Opportunities Toward Precision Medicine Keij, Fleur M. Achten, Niek B. Tramper-Stranders, Gerdien A. Allegaert, Karel van Rossum, Annemarie M. C. Reiss, Irwin K. M. Kornelisse, René F. Front Pediatr Pediatrics Bacterial infections remain a major cause of morbidity and mortality in the neonatal period. Therefore, many neonates, including late preterm and term neonates, are exposed to antibiotics in the first weeks of life. Data on the importance of inter-individual differences and disease signatures are accumulating. Differences that may potentially influence treatment requirement and success rate. However, currently, many neonates are treated following a “one size fits all” approach, based on general protocols and standard antibiotic treatment regimens. Precision medicine has emerged in the last years and is perceived as a new, holistic, way of stratifying patients based on large-scale data including patient characteristics and disease specific features. Specific to sepsis, differences in disease susceptibility, disease severity, immune response and pharmacokinetics and -dynamics can be used for the development of treatment algorithms helping clinicians decide when and how to treat a specific patient or a specific subpopulation. In this review, we highlight the current and future developments that could allow transition to a more precise manner of antibiotic treatment in late preterm and term neonates, and propose a research agenda toward precision medicine for neonatal bacterial infections. Frontiers Media S.A. 2021-04-01 /pmc/articles/PMC8049115/ /pubmed/33869108 http://dx.doi.org/10.3389/fped.2021.590969 Text en Copyright © 2021 Keij, Achten, Tramper-Stranders, Allegaert, van Rossum, Reiss and Kornelisse. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Keij, Fleur M. Achten, Niek B. Tramper-Stranders, Gerdien A. Allegaert, Karel van Rossum, Annemarie M. C. Reiss, Irwin K. M. Kornelisse, René F. Stratified Management for Bacterial Infections in Late Preterm and Term Neonates: Current Strategies and Future Opportunities Toward Precision Medicine |
title | Stratified Management for Bacterial Infections in Late Preterm and Term Neonates: Current Strategies and Future Opportunities Toward Precision Medicine |
title_full | Stratified Management for Bacterial Infections in Late Preterm and Term Neonates: Current Strategies and Future Opportunities Toward Precision Medicine |
title_fullStr | Stratified Management for Bacterial Infections in Late Preterm and Term Neonates: Current Strategies and Future Opportunities Toward Precision Medicine |
title_full_unstemmed | Stratified Management for Bacterial Infections in Late Preterm and Term Neonates: Current Strategies and Future Opportunities Toward Precision Medicine |
title_short | Stratified Management for Bacterial Infections in Late Preterm and Term Neonates: Current Strategies and Future Opportunities Toward Precision Medicine |
title_sort | stratified management for bacterial infections in late preterm and term neonates: current strategies and future opportunities toward precision medicine |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049115/ https://www.ncbi.nlm.nih.gov/pubmed/33869108 http://dx.doi.org/10.3389/fped.2021.590969 |
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