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Case Report: Maintenance of Desensitization to Nebulized Colomycin Over 10 Years
Drug desensitization can be achieved successfully by gradual drug dose increases in different protocols. Most protocols are designed to obtain temporal tolerance. The data on long-term maintenance of drug tolerance is scarce. Based on an IgE-mediated colomycin allergy we describe the maintenance of...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049140/ https://www.ncbi.nlm.nih.gov/pubmed/33869120 http://dx.doi.org/10.3389/fped.2021.663228 |
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author | Sieber, Justyna Renner, Sabine Lakatos-Krepcik, Andrea Szépfalusi, Zsolt |
author_facet | Sieber, Justyna Renner, Sabine Lakatos-Krepcik, Andrea Szépfalusi, Zsolt |
author_sort | Sieber, Justyna |
collection | PubMed |
description | Drug desensitization can be achieved successfully by gradual drug dose increases in different protocols. Most protocols are designed to obtain temporal tolerance. The data on long-term maintenance of drug tolerance is scarce. Based on an IgE-mediated colomycin allergy we describe the maintenance of drug tolerance to nebulized drug for the period of 10 years in a 15-year-old cystic fibrosis patient, proceeded by successful rush intravenous desensitization protocol. The mechanism of drug tolerance is largely speculative; however, long-term maintenance of it seems achievable by continuous local drug application. |
format | Online Article Text |
id | pubmed-8049140 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80491402021-04-16 Case Report: Maintenance of Desensitization to Nebulized Colomycin Over 10 Years Sieber, Justyna Renner, Sabine Lakatos-Krepcik, Andrea Szépfalusi, Zsolt Front Pediatr Pediatrics Drug desensitization can be achieved successfully by gradual drug dose increases in different protocols. Most protocols are designed to obtain temporal tolerance. The data on long-term maintenance of drug tolerance is scarce. Based on an IgE-mediated colomycin allergy we describe the maintenance of drug tolerance to nebulized drug for the period of 10 years in a 15-year-old cystic fibrosis patient, proceeded by successful rush intravenous desensitization protocol. The mechanism of drug tolerance is largely speculative; however, long-term maintenance of it seems achievable by continuous local drug application. Frontiers Media S.A. 2021-04-01 /pmc/articles/PMC8049140/ /pubmed/33869120 http://dx.doi.org/10.3389/fped.2021.663228 Text en Copyright © 2021 Sieber, Renner, Lakatos-Krepcik and Szépfalusi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Sieber, Justyna Renner, Sabine Lakatos-Krepcik, Andrea Szépfalusi, Zsolt Case Report: Maintenance of Desensitization to Nebulized Colomycin Over 10 Years |
title | Case Report: Maintenance of Desensitization to Nebulized Colomycin Over 10 Years |
title_full | Case Report: Maintenance of Desensitization to Nebulized Colomycin Over 10 Years |
title_fullStr | Case Report: Maintenance of Desensitization to Nebulized Colomycin Over 10 Years |
title_full_unstemmed | Case Report: Maintenance of Desensitization to Nebulized Colomycin Over 10 Years |
title_short | Case Report: Maintenance of Desensitization to Nebulized Colomycin Over 10 Years |
title_sort | case report: maintenance of desensitization to nebulized colomycin over 10 years |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049140/ https://www.ncbi.nlm.nih.gov/pubmed/33869120 http://dx.doi.org/10.3389/fped.2021.663228 |
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