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Case Report: Maintenance of Desensitization to Nebulized Colomycin Over 10 Years

Drug desensitization can be achieved successfully by gradual drug dose increases in different protocols. Most protocols are designed to obtain temporal tolerance. The data on long-term maintenance of drug tolerance is scarce. Based on an IgE-mediated colomycin allergy we describe the maintenance of...

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Autores principales: Sieber, Justyna, Renner, Sabine, Lakatos-Krepcik, Andrea, Szépfalusi, Zsolt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049140/
https://www.ncbi.nlm.nih.gov/pubmed/33869120
http://dx.doi.org/10.3389/fped.2021.663228
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author Sieber, Justyna
Renner, Sabine
Lakatos-Krepcik, Andrea
Szépfalusi, Zsolt
author_facet Sieber, Justyna
Renner, Sabine
Lakatos-Krepcik, Andrea
Szépfalusi, Zsolt
author_sort Sieber, Justyna
collection PubMed
description Drug desensitization can be achieved successfully by gradual drug dose increases in different protocols. Most protocols are designed to obtain temporal tolerance. The data on long-term maintenance of drug tolerance is scarce. Based on an IgE-mediated colomycin allergy we describe the maintenance of drug tolerance to nebulized drug for the period of 10 years in a 15-year-old cystic fibrosis patient, proceeded by successful rush intravenous desensitization protocol. The mechanism of drug tolerance is largely speculative; however, long-term maintenance of it seems achievable by continuous local drug application.
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spelling pubmed-80491402021-04-16 Case Report: Maintenance of Desensitization to Nebulized Colomycin Over 10 Years Sieber, Justyna Renner, Sabine Lakatos-Krepcik, Andrea Szépfalusi, Zsolt Front Pediatr Pediatrics Drug desensitization can be achieved successfully by gradual drug dose increases in different protocols. Most protocols are designed to obtain temporal tolerance. The data on long-term maintenance of drug tolerance is scarce. Based on an IgE-mediated colomycin allergy we describe the maintenance of drug tolerance to nebulized drug for the period of 10 years in a 15-year-old cystic fibrosis patient, proceeded by successful rush intravenous desensitization protocol. The mechanism of drug tolerance is largely speculative; however, long-term maintenance of it seems achievable by continuous local drug application. Frontiers Media S.A. 2021-04-01 /pmc/articles/PMC8049140/ /pubmed/33869120 http://dx.doi.org/10.3389/fped.2021.663228 Text en Copyright © 2021 Sieber, Renner, Lakatos-Krepcik and Szépfalusi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Sieber, Justyna
Renner, Sabine
Lakatos-Krepcik, Andrea
Szépfalusi, Zsolt
Case Report: Maintenance of Desensitization to Nebulized Colomycin Over 10 Years
title Case Report: Maintenance of Desensitization to Nebulized Colomycin Over 10 Years
title_full Case Report: Maintenance of Desensitization to Nebulized Colomycin Over 10 Years
title_fullStr Case Report: Maintenance of Desensitization to Nebulized Colomycin Over 10 Years
title_full_unstemmed Case Report: Maintenance of Desensitization to Nebulized Colomycin Over 10 Years
title_short Case Report: Maintenance of Desensitization to Nebulized Colomycin Over 10 Years
title_sort case report: maintenance of desensitization to nebulized colomycin over 10 years
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049140/
https://www.ncbi.nlm.nih.gov/pubmed/33869120
http://dx.doi.org/10.3389/fped.2021.663228
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