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Development of gut microbiota and bifidobacterial communities of neonates in the first 6 weeks and their inheritance from mother

Microbiota especially Bifidobacterium play an important role in adjusting and maintaining homeostatic balance within the infant intestine. The aim of this study was to elucidate the relationship between maternal and infant gut microbiota and identify the Bifidobacterium species that may transfer fro...

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Autores principales: Yang, Bo, Ding, Mengfan, Chen, Yingqi, Han, Fengzhen, Yang, Chunyan, Zhao, Jianxin, Malard, Patrice, Stanton, Catherine, Ross, R. Paul, Zhang, Hao, Chen, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049200/
https://www.ncbi.nlm.nih.gov/pubmed/33847206
http://dx.doi.org/10.1080/19490976.2021.1908100
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author Yang, Bo
Ding, Mengfan
Chen, Yingqi
Han, Fengzhen
Yang, Chunyan
Zhao, Jianxin
Malard, Patrice
Stanton, Catherine
Ross, R. Paul
Zhang, Hao
Chen, Wei
author_facet Yang, Bo
Ding, Mengfan
Chen, Yingqi
Han, Fengzhen
Yang, Chunyan
Zhao, Jianxin
Malard, Patrice
Stanton, Catherine
Ross, R. Paul
Zhang, Hao
Chen, Wei
author_sort Yang, Bo
collection PubMed
description Microbiota especially Bifidobacterium play an important role in adjusting and maintaining homeostatic balance within the infant intestine. The aim of this study was to elucidate the relationship between maternal and infant gut microbiota and identify the Bifidobacterium species that may transfer from mother to infant over the first 42 days of the infant’s life. Nineteen mother-infant-pair fecal samples were collected and the diversity and composition of the total bacterial and Bifidobacterium communities were analyzed via 16S rDNA and bifidobacterial groEL gene high throughput sequencing. The results revealed that the relative abundance of Bifidobacterium was significantly higher in the infant gut while Parabacteroides, Blautia, Coprococcus, Lachnospira and Faecalibacterium were at lower relative abundance in 7-day and 42-day infant fecal samples compared to the maternal samples. The maternal gut has more B. pseudocatenulatum. In the infant group, B. breve and B. dentium relative abundance increased while B. animalis subsp. lactis decreased from days 7 to 42. Additionally, B. longum subsp. longum isolated from FGZ16 and FGZ35 may have transferred from mother to infant and colonized the infant gut. The results of the current study provide insight toward the infant gut microbiota composition and structure during the first 42 days and may help guide Bifidobacterium supplementation strategies in mothers and infants.
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spelling pubmed-80492002021-04-26 Development of gut microbiota and bifidobacterial communities of neonates in the first 6 weeks and their inheritance from mother Yang, Bo Ding, Mengfan Chen, Yingqi Han, Fengzhen Yang, Chunyan Zhao, Jianxin Malard, Patrice Stanton, Catherine Ross, R. Paul Zhang, Hao Chen, Wei Gut Microbes Research Paper Microbiota especially Bifidobacterium play an important role in adjusting and maintaining homeostatic balance within the infant intestine. The aim of this study was to elucidate the relationship between maternal and infant gut microbiota and identify the Bifidobacterium species that may transfer from mother to infant over the first 42 days of the infant’s life. Nineteen mother-infant-pair fecal samples were collected and the diversity and composition of the total bacterial and Bifidobacterium communities were analyzed via 16S rDNA and bifidobacterial groEL gene high throughput sequencing. The results revealed that the relative abundance of Bifidobacterium was significantly higher in the infant gut while Parabacteroides, Blautia, Coprococcus, Lachnospira and Faecalibacterium were at lower relative abundance in 7-day and 42-day infant fecal samples compared to the maternal samples. The maternal gut has more B. pseudocatenulatum. In the infant group, B. breve and B. dentium relative abundance increased while B. animalis subsp. lactis decreased from days 7 to 42. Additionally, B. longum subsp. longum isolated from FGZ16 and FGZ35 may have transferred from mother to infant and colonized the infant gut. The results of the current study provide insight toward the infant gut microbiota composition and structure during the first 42 days and may help guide Bifidobacterium supplementation strategies in mothers and infants. Taylor & Francis 2021-04-13 /pmc/articles/PMC8049200/ /pubmed/33847206 http://dx.doi.org/10.1080/19490976.2021.1908100 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Yang, Bo
Ding, Mengfan
Chen, Yingqi
Han, Fengzhen
Yang, Chunyan
Zhao, Jianxin
Malard, Patrice
Stanton, Catherine
Ross, R. Paul
Zhang, Hao
Chen, Wei
Development of gut microbiota and bifidobacterial communities of neonates in the first 6 weeks and their inheritance from mother
title Development of gut microbiota and bifidobacterial communities of neonates in the first 6 weeks and their inheritance from mother
title_full Development of gut microbiota and bifidobacterial communities of neonates in the first 6 weeks and their inheritance from mother
title_fullStr Development of gut microbiota and bifidobacterial communities of neonates in the first 6 weeks and their inheritance from mother
title_full_unstemmed Development of gut microbiota and bifidobacterial communities of neonates in the first 6 weeks and their inheritance from mother
title_short Development of gut microbiota and bifidobacterial communities of neonates in the first 6 weeks and their inheritance from mother
title_sort development of gut microbiota and bifidobacterial communities of neonates in the first 6 weeks and their inheritance from mother
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049200/
https://www.ncbi.nlm.nih.gov/pubmed/33847206
http://dx.doi.org/10.1080/19490976.2021.1908100
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