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Laboratory correlates of SARS-CoV-2 seropositivity in a nationwide sample of patients on dialysis in the U.S.

Patients on dialysis are at high risk for death due to COVID-19, yet a significant proportion do survive as evidenced by presence of SARS-CoV-2 antibodies in 8% of patients in the U.S. in July 2020. It is unclear whether patients with seropositivity represent the subgroup with robust health status,...

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Autores principales: Anand, Shuchi, Montez-Rath, Maria E., Han, Jialin, Garcia, Pablo, Bozeman, Julie, Kerschmann, Russell, Beyer, Paul, Parsonnet, Julie, Chertow, Glenn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049224/
https://www.ncbi.nlm.nih.gov/pubmed/33857168
http://dx.doi.org/10.1371/journal.pone.0249466
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author Anand, Shuchi
Montez-Rath, Maria E.
Han, Jialin
Garcia, Pablo
Bozeman, Julie
Kerschmann, Russell
Beyer, Paul
Parsonnet, Julie
Chertow, Glenn M.
author_facet Anand, Shuchi
Montez-Rath, Maria E.
Han, Jialin
Garcia, Pablo
Bozeman, Julie
Kerschmann, Russell
Beyer, Paul
Parsonnet, Julie
Chertow, Glenn M.
author_sort Anand, Shuchi
collection PubMed
description Patients on dialysis are at high risk for death due to COVID-19, yet a significant proportion do survive as evidenced by presence of SARS-CoV-2 antibodies in 8% of patients in the U.S. in July 2020. It is unclear whether patients with seropositivity represent the subgroup with robust health status, who would be more likely to mount a durable antibody response. Using data from a July 2020 sample of 28,503 patients receiving dialysis, we evaluated the cross-sectional association of SARS-CoV-2 seropositivity with laboratory surrogates of patient health. In separate logistic regression models, we assessed the association of SARS-CoV-2 seropositivity with seven laboratory-based covariates (albumin, creatinine, hemoglobin, sodium, potassium, phosphate, and parathyroid hormone), across the entire range of the laboratory and in comparison to a referent value. Models accounted for age, sex, region, race and ethnicity, and county-level COVID-19 deaths per 100,000. Odds of seropositivity for albumin 3 and 3.5 g/dL were 2.1 (95% CI 1.9–2.3) and 1.3 (1.2–1.4) respectively, compared with 4 g/dL. Odds of seropositivity for serum creatinine 5 and 8 mg/dL were 1.8 (1.6–2.0) and 1.3 (1.2–1.4) respectively, compared with 12.5 mg/dL. Lower values of hemoglobin, sodium, potassium, phosphate, and parathyroid hormone were associated with higher odds of seropositivity. Laboratory values associated with poorer health status and higher risk for mortality were also associated with higher likelihood of SARS-CoV-2 antibodies in patients receiving dialysis.
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spelling pubmed-80492242021-04-21 Laboratory correlates of SARS-CoV-2 seropositivity in a nationwide sample of patients on dialysis in the U.S. Anand, Shuchi Montez-Rath, Maria E. Han, Jialin Garcia, Pablo Bozeman, Julie Kerschmann, Russell Beyer, Paul Parsonnet, Julie Chertow, Glenn M. PLoS One Research Article Patients on dialysis are at high risk for death due to COVID-19, yet a significant proportion do survive as evidenced by presence of SARS-CoV-2 antibodies in 8% of patients in the U.S. in July 2020. It is unclear whether patients with seropositivity represent the subgroup with robust health status, who would be more likely to mount a durable antibody response. Using data from a July 2020 sample of 28,503 patients receiving dialysis, we evaluated the cross-sectional association of SARS-CoV-2 seropositivity with laboratory surrogates of patient health. In separate logistic regression models, we assessed the association of SARS-CoV-2 seropositivity with seven laboratory-based covariates (albumin, creatinine, hemoglobin, sodium, potassium, phosphate, and parathyroid hormone), across the entire range of the laboratory and in comparison to a referent value. Models accounted for age, sex, region, race and ethnicity, and county-level COVID-19 deaths per 100,000. Odds of seropositivity for albumin 3 and 3.5 g/dL were 2.1 (95% CI 1.9–2.3) and 1.3 (1.2–1.4) respectively, compared with 4 g/dL. Odds of seropositivity for serum creatinine 5 and 8 mg/dL were 1.8 (1.6–2.0) and 1.3 (1.2–1.4) respectively, compared with 12.5 mg/dL. Lower values of hemoglobin, sodium, potassium, phosphate, and parathyroid hormone were associated with higher odds of seropositivity. Laboratory values associated with poorer health status and higher risk for mortality were also associated with higher likelihood of SARS-CoV-2 antibodies in patients receiving dialysis. Public Library of Science 2021-04-15 /pmc/articles/PMC8049224/ /pubmed/33857168 http://dx.doi.org/10.1371/journal.pone.0249466 Text en © 2021 Anand et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Anand, Shuchi
Montez-Rath, Maria E.
Han, Jialin
Garcia, Pablo
Bozeman, Julie
Kerschmann, Russell
Beyer, Paul
Parsonnet, Julie
Chertow, Glenn M.
Laboratory correlates of SARS-CoV-2 seropositivity in a nationwide sample of patients on dialysis in the U.S.
title Laboratory correlates of SARS-CoV-2 seropositivity in a nationwide sample of patients on dialysis in the U.S.
title_full Laboratory correlates of SARS-CoV-2 seropositivity in a nationwide sample of patients on dialysis in the U.S.
title_fullStr Laboratory correlates of SARS-CoV-2 seropositivity in a nationwide sample of patients on dialysis in the U.S.
title_full_unstemmed Laboratory correlates of SARS-CoV-2 seropositivity in a nationwide sample of patients on dialysis in the U.S.
title_short Laboratory correlates of SARS-CoV-2 seropositivity in a nationwide sample of patients on dialysis in the U.S.
title_sort laboratory correlates of sars-cov-2 seropositivity in a nationwide sample of patients on dialysis in the u.s.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049224/
https://www.ncbi.nlm.nih.gov/pubmed/33857168
http://dx.doi.org/10.1371/journal.pone.0249466
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