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Emerging Role of Exosomes in Retinal Diseases
Retinal diseases, the leading causes of vison loss and blindness, are associated with complicated pathogeneses such as angiogenesis, inflammation, immune regulation, fibrous proliferation, and neurodegeneration. The retina is a complex tissue, where the various resident cell types communicate betwee...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049503/ https://www.ncbi.nlm.nih.gov/pubmed/33869195 http://dx.doi.org/10.3389/fcell.2021.643680 |
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author | Zhang, Zhengyu Mugisha, Aime Fransisca, Silvia Liu, Qinghuai Xie, Ping Hu, Zizhong |
author_facet | Zhang, Zhengyu Mugisha, Aime Fransisca, Silvia Liu, Qinghuai Xie, Ping Hu, Zizhong |
author_sort | Zhang, Zhengyu |
collection | PubMed |
description | Retinal diseases, the leading causes of vison loss and blindness, are associated with complicated pathogeneses such as angiogenesis, inflammation, immune regulation, fibrous proliferation, and neurodegeneration. The retina is a complex tissue, where the various resident cell types communicate between themselves and with cells from the blood and immune systems. Exosomes, which are bilayer membrane vesicles with diameters of 30–150 nm, carry a variety of proteins, lipids, and nucleic acids, and participate in cell-to-cell communication. Recently, the roles of exosomes in pathophysiological process and their therapeutic potential have been emerging. Here, we critically review the roles of exosomes as possible intracellular mediators and discuss the possibility of using exosomes as therapeutic agents in retinal diseases. |
format | Online Article Text |
id | pubmed-8049503 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-80495032021-04-16 Emerging Role of Exosomes in Retinal Diseases Zhang, Zhengyu Mugisha, Aime Fransisca, Silvia Liu, Qinghuai Xie, Ping Hu, Zizhong Front Cell Dev Biol Cell and Developmental Biology Retinal diseases, the leading causes of vison loss and blindness, are associated with complicated pathogeneses such as angiogenesis, inflammation, immune regulation, fibrous proliferation, and neurodegeneration. The retina is a complex tissue, where the various resident cell types communicate between themselves and with cells from the blood and immune systems. Exosomes, which are bilayer membrane vesicles with diameters of 30–150 nm, carry a variety of proteins, lipids, and nucleic acids, and participate in cell-to-cell communication. Recently, the roles of exosomes in pathophysiological process and their therapeutic potential have been emerging. Here, we critically review the roles of exosomes as possible intracellular mediators and discuss the possibility of using exosomes as therapeutic agents in retinal diseases. Frontiers Media S.A. 2021-04-01 /pmc/articles/PMC8049503/ /pubmed/33869195 http://dx.doi.org/10.3389/fcell.2021.643680 Text en Copyright © 2021 Zhang, Mugisha, Fransisca, Liu, Xie and Hu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Zhang, Zhengyu Mugisha, Aime Fransisca, Silvia Liu, Qinghuai Xie, Ping Hu, Zizhong Emerging Role of Exosomes in Retinal Diseases |
title | Emerging Role of Exosomes in Retinal Diseases |
title_full | Emerging Role of Exosomes in Retinal Diseases |
title_fullStr | Emerging Role of Exosomes in Retinal Diseases |
title_full_unstemmed | Emerging Role of Exosomes in Retinal Diseases |
title_short | Emerging Role of Exosomes in Retinal Diseases |
title_sort | emerging role of exosomes in retinal diseases |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049503/ https://www.ncbi.nlm.nih.gov/pubmed/33869195 http://dx.doi.org/10.3389/fcell.2021.643680 |
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