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How COVID-19 has fundamentally changed clinical research in global health

COVID-19 has had negative repercussions on the entire global population. Despite there being a common goal that should have unified resources and efforts, there have been an overwhelmingly large number of clinical trials that have been registered that are of questionable methodological quality. As t...

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Autores principales: Park, Jay J H, Mogg, Robin, Smith, Gerald E, Nakimuli-Mpungu, Etheldreda, Jehan, Fyezah, Rayner, Craig R, Condo, Jeanine, Decloedt, Eric H, Nachega, Jean B, Reis, Gilmar, Mills, Edward J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). Published by Elsevier Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049590/
https://www.ncbi.nlm.nih.gov/pubmed/33865476
http://dx.doi.org/10.1016/S2214-109X(20)30542-8
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author Park, Jay J H
Mogg, Robin
Smith, Gerald E
Nakimuli-Mpungu, Etheldreda
Jehan, Fyezah
Rayner, Craig R
Condo, Jeanine
Decloedt, Eric H
Nachega, Jean B
Reis, Gilmar
Mills, Edward J
author_facet Park, Jay J H
Mogg, Robin
Smith, Gerald E
Nakimuli-Mpungu, Etheldreda
Jehan, Fyezah
Rayner, Craig R
Condo, Jeanine
Decloedt, Eric H
Nachega, Jean B
Reis, Gilmar
Mills, Edward J
author_sort Park, Jay J H
collection PubMed
description COVID-19 has had negative repercussions on the entire global population. Despite there being a common goal that should have unified resources and efforts, there have been an overwhelmingly large number of clinical trials that have been registered that are of questionable methodological quality. As the final paper of this Series, we discuss how the medical research community has responded to COVID-19. We recognise the incredible pressure that this pandemic has put on researchers, regulators, and policy makers, all of whom were doing their best to move quickly but safely in a time of tremendous uncertainty. However, the research community's response to the COVID-19 pandemic has prominently highlighted many fundamental issues that exist in clinical trial research under the current system and its incentive structures. The COVID-19 pandemic has not only re-emphasised the importance of well designed randomised clinical trials but also highlighted the need for large-scale clinical trials structured according to a master protocol in a coordinated and collaborative manner. There is also a need for structures and incentives to enable faster data sharing of anonymised datasets, and a need to provide similar opportunities to those in high-income countries for clinical trial research in low-resource regions where clinical trial research receives considerably less research funding.
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spelling pubmed-80495902021-04-16 How COVID-19 has fundamentally changed clinical research in global health Park, Jay J H Mogg, Robin Smith, Gerald E Nakimuli-Mpungu, Etheldreda Jehan, Fyezah Rayner, Craig R Condo, Jeanine Decloedt, Eric H Nachega, Jean B Reis, Gilmar Mills, Edward J Lancet Glob Health Series COVID-19 has had negative repercussions on the entire global population. Despite there being a common goal that should have unified resources and efforts, there have been an overwhelmingly large number of clinical trials that have been registered that are of questionable methodological quality. As the final paper of this Series, we discuss how the medical research community has responded to COVID-19. We recognise the incredible pressure that this pandemic has put on researchers, regulators, and policy makers, all of whom were doing their best to move quickly but safely in a time of tremendous uncertainty. However, the research community's response to the COVID-19 pandemic has prominently highlighted many fundamental issues that exist in clinical trial research under the current system and its incentive structures. The COVID-19 pandemic has not only re-emphasised the importance of well designed randomised clinical trials but also highlighted the need for large-scale clinical trials structured according to a master protocol in a coordinated and collaborative manner. There is also a need for structures and incentives to enable faster data sharing of anonymised datasets, and a need to provide similar opportunities to those in high-income countries for clinical trial research in low-resource regions where clinical trial research receives considerably less research funding. The Author(s). Published by Elsevier Ltd. 2021-05 2021-04-15 /pmc/articles/PMC8049590/ /pubmed/33865476 http://dx.doi.org/10.1016/S2214-109X(20)30542-8 Text en © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Series
Park, Jay J H
Mogg, Robin
Smith, Gerald E
Nakimuli-Mpungu, Etheldreda
Jehan, Fyezah
Rayner, Craig R
Condo, Jeanine
Decloedt, Eric H
Nachega, Jean B
Reis, Gilmar
Mills, Edward J
How COVID-19 has fundamentally changed clinical research in global health
title How COVID-19 has fundamentally changed clinical research in global health
title_full How COVID-19 has fundamentally changed clinical research in global health
title_fullStr How COVID-19 has fundamentally changed clinical research in global health
title_full_unstemmed How COVID-19 has fundamentally changed clinical research in global health
title_short How COVID-19 has fundamentally changed clinical research in global health
title_sort how covid-19 has fundamentally changed clinical research in global health
topic Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049590/
https://www.ncbi.nlm.nih.gov/pubmed/33865476
http://dx.doi.org/10.1016/S2214-109X(20)30542-8
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