A Rare Case of Diffuse Neurofibroma of the Scalp With Destructive Lesions Involving the Base of the Skull in a Patient With Neurofibromatosis Type 1

Diffuse neurofibroma is a benign tumor of peripheral nerves. Ten percent of neurofibromatosis type 1 (NF-1) patients can develop diffuse neurofibroma. Here, we report a case of diffuse neurofibroma involving the base of the skull in a 50-years-old patient with NF-1. The patient presented with diffus...

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Autores principales: Maqsood, Hamza, Saim, Muhammad, Anjum, Abdul Sattar, Younus, Shifa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049738/
https://www.ncbi.nlm.nih.gov/pubmed/33868861
http://dx.doi.org/10.7759/cureus.13930
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author Maqsood, Hamza
Saim, Muhammad
Anjum, Abdul Sattar
Younus, Shifa
author_facet Maqsood, Hamza
Saim, Muhammad
Anjum, Abdul Sattar
Younus, Shifa
author_sort Maqsood, Hamza
collection PubMed
description Diffuse neurofibroma is a benign tumor of peripheral nerves. Ten percent of neurofibromatosis type 1 (NF-1) patients can develop diffuse neurofibroma. Here, we report a case of diffuse neurofibroma involving the base of the skull in a 50-years-old patient with NF-1. The patient presented with diffuse involvement of the scalp with soft and mobile masses. Radiological investigations revealed skull bone lesions. Aggressive osteolytic lesions involving the base of the skull were present. Surgical excision with the repairing of the defects was suggested but the patient refused the treatment. The diagnosis of calvarial defects in diffuse neurofibroma is challenging. Early diagnosis can help in better management of the patients.
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spelling pubmed-80497382021-04-16 A Rare Case of Diffuse Neurofibroma of the Scalp With Destructive Lesions Involving the Base of the Skull in a Patient With Neurofibromatosis Type 1 Maqsood, Hamza Saim, Muhammad Anjum, Abdul Sattar Younus, Shifa Cureus Neurology Diffuse neurofibroma is a benign tumor of peripheral nerves. Ten percent of neurofibromatosis type 1 (NF-1) patients can develop diffuse neurofibroma. Here, we report a case of diffuse neurofibroma involving the base of the skull in a 50-years-old patient with NF-1. The patient presented with diffuse involvement of the scalp with soft and mobile masses. Radiological investigations revealed skull bone lesions. Aggressive osteolytic lesions involving the base of the skull were present. Surgical excision with the repairing of the defects was suggested but the patient refused the treatment. The diagnosis of calvarial defects in diffuse neurofibroma is challenging. Early diagnosis can help in better management of the patients. Cureus 2021-03-16 /pmc/articles/PMC8049738/ /pubmed/33868861 http://dx.doi.org/10.7759/cureus.13930 Text en Copyright © 2021, Maqsood et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurology
Maqsood, Hamza
Saim, Muhammad
Anjum, Abdul Sattar
Younus, Shifa
A Rare Case of Diffuse Neurofibroma of the Scalp With Destructive Lesions Involving the Base of the Skull in a Patient With Neurofibromatosis Type 1
title A Rare Case of Diffuse Neurofibroma of the Scalp With Destructive Lesions Involving the Base of the Skull in a Patient With Neurofibromatosis Type 1
title_full A Rare Case of Diffuse Neurofibroma of the Scalp With Destructive Lesions Involving the Base of the Skull in a Patient With Neurofibromatosis Type 1
title_fullStr A Rare Case of Diffuse Neurofibroma of the Scalp With Destructive Lesions Involving the Base of the Skull in a Patient With Neurofibromatosis Type 1
title_full_unstemmed A Rare Case of Diffuse Neurofibroma of the Scalp With Destructive Lesions Involving the Base of the Skull in a Patient With Neurofibromatosis Type 1
title_short A Rare Case of Diffuse Neurofibroma of the Scalp With Destructive Lesions Involving the Base of the Skull in a Patient With Neurofibromatosis Type 1
title_sort rare case of diffuse neurofibroma of the scalp with destructive lesions involving the base of the skull in a patient with neurofibromatosis type 1
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049738/
https://www.ncbi.nlm.nih.gov/pubmed/33868861
http://dx.doi.org/10.7759/cureus.13930
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