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Circulating dipeptidyl peptidase-4 is independently associated with the presence and severity of NAFLD/NASH in individuals with and without obesity and metabolic disease

INTRODUCTION: Dipeptidyl peptidase 4 (DPP4) levels are associated to metabolic and cardiovascular diseases in humans; initial evidence reported a relationship between DPP4 and chronic liver diseases. Aim of this study was to investigate hepatic and systemic DPP4 levels/activity in relation to NAFLD/...

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Autores principales: Barchetta, Ilaria, Ceccarelli, Valentina, Cimini, Flavia A., Barone, Eugenio, Sentinelli, Federica, Coluzzi, Mariagrazia, Chiappetta, Caterina, Bertoccini, Laura, Tramutola, Antonella, Labbadia, Giancarlo, Di Cristofano, Claudio, Silecchia, Gianfranco, Leonetti, Frida, Cavallo, Maria G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049937/
https://www.ncbi.nlm.nih.gov/pubmed/32852705
http://dx.doi.org/10.1007/s40618-020-01392-5
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author Barchetta, Ilaria
Ceccarelli, Valentina
Cimini, Flavia A.
Barone, Eugenio
Sentinelli, Federica
Coluzzi, Mariagrazia
Chiappetta, Caterina
Bertoccini, Laura
Tramutola, Antonella
Labbadia, Giancarlo
Di Cristofano, Claudio
Silecchia, Gianfranco
Leonetti, Frida
Cavallo, Maria G.
author_facet Barchetta, Ilaria
Ceccarelli, Valentina
Cimini, Flavia A.
Barone, Eugenio
Sentinelli, Federica
Coluzzi, Mariagrazia
Chiappetta, Caterina
Bertoccini, Laura
Tramutola, Antonella
Labbadia, Giancarlo
Di Cristofano, Claudio
Silecchia, Gianfranco
Leonetti, Frida
Cavallo, Maria G.
author_sort Barchetta, Ilaria
collection PubMed
description INTRODUCTION: Dipeptidyl peptidase 4 (DPP4) levels are associated to metabolic and cardiovascular diseases in humans; initial evidence reported a relationship between DPP4 and chronic liver diseases. Aim of this study was to investigate hepatic and systemic DPP4 levels/activity in relation to NAFLD/NASH in individuals with and without metabolic disease. METHODS: We recruited fifty-two obese individuals undergoing bariatric surgery and intra-operative liver biopsy at Sapienza University, Rome, Italy. The association between DPP4 levels/activity and NAFLD was also evaluated in 126 non-obese individuals recruited in the same setting. RESULTS: NAFLD patients had significantly higher circulating DPP4 activity than no-NAFLD in both the obese and non-obese cohorts; plasma DPP4 activity and levels linearly correlated with steatosis grade and inflammation at the liver biopsy. Hepatic DPP4 mRNA was not associated to either its circulating levels/activity or NAFLD. In the multivariate logistic regression analysis on all the study participants (n = 178), higher circulating DPP4 activity was associated with NAFLD independently of potential confounders with OR (95% CI): 3.5 (1.2–10.21), p = 0.022. CONCLUSIONS: This study demonstrates the coexistence of increased plasma DPP4 levels and activity in NAFLD. Circulating DPP4 measurement may represent a novel cost-effective strategy for NAFLD/NASH risk stratification and a potential tool for monitoring disease’s progression in established NAFLD.
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spelling pubmed-80499372021-04-29 Circulating dipeptidyl peptidase-4 is independently associated with the presence and severity of NAFLD/NASH in individuals with and without obesity and metabolic disease Barchetta, Ilaria Ceccarelli, Valentina Cimini, Flavia A. Barone, Eugenio Sentinelli, Federica Coluzzi, Mariagrazia Chiappetta, Caterina Bertoccini, Laura Tramutola, Antonella Labbadia, Giancarlo Di Cristofano, Claudio Silecchia, Gianfranco Leonetti, Frida Cavallo, Maria G. J Endocrinol Invest Original Article INTRODUCTION: Dipeptidyl peptidase 4 (DPP4) levels are associated to metabolic and cardiovascular diseases in humans; initial evidence reported a relationship between DPP4 and chronic liver diseases. Aim of this study was to investigate hepatic and systemic DPP4 levels/activity in relation to NAFLD/NASH in individuals with and without metabolic disease. METHODS: We recruited fifty-two obese individuals undergoing bariatric surgery and intra-operative liver biopsy at Sapienza University, Rome, Italy. The association between DPP4 levels/activity and NAFLD was also evaluated in 126 non-obese individuals recruited in the same setting. RESULTS: NAFLD patients had significantly higher circulating DPP4 activity than no-NAFLD in both the obese and non-obese cohorts; plasma DPP4 activity and levels linearly correlated with steatosis grade and inflammation at the liver biopsy. Hepatic DPP4 mRNA was not associated to either its circulating levels/activity or NAFLD. In the multivariate logistic regression analysis on all the study participants (n = 178), higher circulating DPP4 activity was associated with NAFLD independently of potential confounders with OR (95% CI): 3.5 (1.2–10.21), p = 0.022. CONCLUSIONS: This study demonstrates the coexistence of increased plasma DPP4 levels and activity in NAFLD. Circulating DPP4 measurement may represent a novel cost-effective strategy for NAFLD/NASH risk stratification and a potential tool for monitoring disease’s progression in established NAFLD. Springer International Publishing 2020-08-27 2021 /pmc/articles/PMC8049937/ /pubmed/32852705 http://dx.doi.org/10.1007/s40618-020-01392-5 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Barchetta, Ilaria
Ceccarelli, Valentina
Cimini, Flavia A.
Barone, Eugenio
Sentinelli, Federica
Coluzzi, Mariagrazia
Chiappetta, Caterina
Bertoccini, Laura
Tramutola, Antonella
Labbadia, Giancarlo
Di Cristofano, Claudio
Silecchia, Gianfranco
Leonetti, Frida
Cavallo, Maria G.
Circulating dipeptidyl peptidase-4 is independently associated with the presence and severity of NAFLD/NASH in individuals with and without obesity and metabolic disease
title Circulating dipeptidyl peptidase-4 is independently associated with the presence and severity of NAFLD/NASH in individuals with and without obesity and metabolic disease
title_full Circulating dipeptidyl peptidase-4 is independently associated with the presence and severity of NAFLD/NASH in individuals with and without obesity and metabolic disease
title_fullStr Circulating dipeptidyl peptidase-4 is independently associated with the presence and severity of NAFLD/NASH in individuals with and without obesity and metabolic disease
title_full_unstemmed Circulating dipeptidyl peptidase-4 is independently associated with the presence and severity of NAFLD/NASH in individuals with and without obesity and metabolic disease
title_short Circulating dipeptidyl peptidase-4 is independently associated with the presence and severity of NAFLD/NASH in individuals with and without obesity and metabolic disease
title_sort circulating dipeptidyl peptidase-4 is independently associated with the presence and severity of nafld/nash in individuals with and without obesity and metabolic disease
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049937/
https://www.ncbi.nlm.nih.gov/pubmed/32852705
http://dx.doi.org/10.1007/s40618-020-01392-5
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