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Endogenous generation of nitro-fatty acid hybrids having dual nitrate ester (RONO(2)) and nitroalkene (RNO(2)) substituents

Organic nitrate esters, long-recognized therapies for cardiovascular disorders, have not been detected biologically. We characterize in rat stomach unsaturated fatty acid nitration reactions that proceed by generation of nitro-nitrate intermediates (NO(2)–ONO(2)-FA) via oxygen and nitrite dependent...

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Detalles Bibliográficos
Autores principales:	Fazzari, Marco, Woodcock, Steven R., Rowart, Pascal, Ricart, Karina, Lancaster, Jack R., Patel, Rakesh, Vitturi, Dario A., Freeman, Bruce A., Schopfer, Francisco J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049994/ https://www.ncbi.nlm.nih.gov/pubmed/33819836 http://dx.doi.org/10.1016/j.redox.2021.101913

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