Modifying the resolving cysteine affects the structure and hydrogen peroxide reactivity of peroxiredoxin 2

Peroxiredoxin 2 (Prdx2) is a thiol peroxidase with an active site Cys (C52) that reacts rapidly with H(2)O(2) and other peroxides. The sulfenic acid product condenses with the resolving Cys (C172) to form a disulfide which is recycled by thioredoxin or GSH via mixed disulfide intermediates or underg...

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Detalles Bibliográficos
Autores principales: Peskin, Alexander V., Meotti, Flavia C., Kean, Kelsey M., Göbl, Christoph, Peixoto, Albert Souza, Pace, Paul E., Horne, Christopher R., Heath, Sarah G., Crowther, Jennifer M., Dobson, Renwick C.J., Karplus, P. Andrew, Winterbourn, Christine C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8049995/
https://www.ncbi.nlm.nih.gov/pubmed/33667550
http://dx.doi.org/10.1016/j.jbc.2021.100494

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