Naturally-occurring spinosyn A and its derivatives function as argininosuccinate synthase activator and tumor inhibitor

Argininosuccinate synthase (ASS1) is a ubiquitous enzyme in mammals that catalyzes the formation of argininosuccinate from citrulline and aspartate. ASS1 genetic deficiency in patients leads to an autosomal recessive urea cycle disorder citrullinemia, while its somatic silence or down-regulation is...

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Detalles Bibliográficos
Autores principales: Zou, Zizheng, Hu, Xiyuan, Luo, Tiao, Ming, Zhengnan, Chen, Xiaodan, Xia, Li, Luo, Wensong, Li, Jijia, Xu, Na, Chen, Ling, Cao, Dongsheng, Wen, Min, Kong, Fanrong, Peng, Kunjian, Xie, Yuanzhu, Li, Xuan, Ma, Dayou, Yang, Chuanyu, Chen, Ceshi, Yi, Wenjun, Liu, Ousheng, Liu, Suyou, Luo, Junli, Luo, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050083/
https://www.ncbi.nlm.nih.gov/pubmed/33859183
http://dx.doi.org/10.1038/s41467-021-22235-8

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