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Quality of life after traumatic brain injury: a cross-sectional analysis uncovers age- and sex-related differences over the adult life span

Traumatic brain injury (TBI) is the leading cause of disability in the working population and becomes increasingly prevalent in the elderly. Thus, TBI is a major global health burden. However, age- and sex-related long-term outcome regarding patient’s health-related quality of life (HRQoL) is yet no...

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Autores principales: Rauen, Katrin, Späni, Claudia B., Tartaglia, Maria Carmela, Ferretti, Maria Teresa, Reichelt, Lara, Probst, Philipp, Schäpers, Barbara, Müller, Friedemann, Jahn, Klaus, Plesnila, Nikolaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050174/
https://www.ncbi.nlm.nih.gov/pubmed/33070278
http://dx.doi.org/10.1007/s11357-020-00273-2
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author Rauen, Katrin
Späni, Claudia B.
Tartaglia, Maria Carmela
Ferretti, Maria Teresa
Reichelt, Lara
Probst, Philipp
Schäpers, Barbara
Müller, Friedemann
Jahn, Klaus
Plesnila, Nikolaus
author_facet Rauen, Katrin
Späni, Claudia B.
Tartaglia, Maria Carmela
Ferretti, Maria Teresa
Reichelt, Lara
Probst, Philipp
Schäpers, Barbara
Müller, Friedemann
Jahn, Klaus
Plesnila, Nikolaus
author_sort Rauen, Katrin
collection PubMed
description Traumatic brain injury (TBI) is the leading cause of disability in the working population and becomes increasingly prevalent in the elderly. Thus, TBI is a major global health burden. However, age- and sex-related long-term outcome regarding patient’s health-related quality of life (HRQoL) is yet not clarified. In this cross-sectional study, we present age- and sex-related demographics and HRQoL up to 10 years after TBI using the Quality of Life after Brain Injury (QOLIBRI) instrument. The QOLIBRI total score ranges from zero to 100 indicating good (≥ 60), moderate (40–59) or unfavorable (< 40) HRQoL. Two-thirds of the entire chronic TBI cohort (102 males; 33 females) aged 18–85 years reported good HRQoL up to 10 years after TBI. TBI etiology differed between sexes with females suffering more often from traffic- than fall-related TBI (p = 0.01) with increasing prevalence during aging (p = < 0.001). HRQoL (good/moderate/unfavorable) differed between sexes (p < 0.0001) with 17% more females reporting moderate outcome (p = 0.01). Specifically, older females (54–76-years at TBI) were affected, while males constantly reported good HRQoL (p = 0.017). Cognition (p = 0.014), self-perception (p = 0.009), and emotions (p = 0.016) rather than physical problems (p = 0.1) constrained older females’ HRQoL after TBI. Experiencing TBI during aging does not influence HRQoL outcome in males but females suggesting that female brains cope less well with a traumatic injury during aging. Therefore, older females need long-term follow-ups after TBI to detect neuropsychiatric sequels that restrict their quality of life. Further investigations are necessary to uncover the mechanisms of this so far unknown phenomenon. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11357-020-00273-2) contains supplementary material, which is available to authorized users.
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spelling pubmed-80501742021-04-30 Quality of life after traumatic brain injury: a cross-sectional analysis uncovers age- and sex-related differences over the adult life span Rauen, Katrin Späni, Claudia B. Tartaglia, Maria Carmela Ferretti, Maria Teresa Reichelt, Lara Probst, Philipp Schäpers, Barbara Müller, Friedemann Jahn, Klaus Plesnila, Nikolaus GeroScience Original Article Traumatic brain injury (TBI) is the leading cause of disability in the working population and becomes increasingly prevalent in the elderly. Thus, TBI is a major global health burden. However, age- and sex-related long-term outcome regarding patient’s health-related quality of life (HRQoL) is yet not clarified. In this cross-sectional study, we present age- and sex-related demographics and HRQoL up to 10 years after TBI using the Quality of Life after Brain Injury (QOLIBRI) instrument. The QOLIBRI total score ranges from zero to 100 indicating good (≥ 60), moderate (40–59) or unfavorable (< 40) HRQoL. Two-thirds of the entire chronic TBI cohort (102 males; 33 females) aged 18–85 years reported good HRQoL up to 10 years after TBI. TBI etiology differed between sexes with females suffering more often from traffic- than fall-related TBI (p = 0.01) with increasing prevalence during aging (p = < 0.001). HRQoL (good/moderate/unfavorable) differed between sexes (p < 0.0001) with 17% more females reporting moderate outcome (p = 0.01). Specifically, older females (54–76-years at TBI) were affected, while males constantly reported good HRQoL (p = 0.017). Cognition (p = 0.014), self-perception (p = 0.009), and emotions (p = 0.016) rather than physical problems (p = 0.1) constrained older females’ HRQoL after TBI. Experiencing TBI during aging does not influence HRQoL outcome in males but females suggesting that female brains cope less well with a traumatic injury during aging. Therefore, older females need long-term follow-ups after TBI to detect neuropsychiatric sequels that restrict their quality of life. Further investigations are necessary to uncover the mechanisms of this so far unknown phenomenon. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s11357-020-00273-2) contains supplementary material, which is available to authorized users. Springer International Publishing 2020-10-17 /pmc/articles/PMC8050174/ /pubmed/33070278 http://dx.doi.org/10.1007/s11357-020-00273-2 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Rauen, Katrin
Späni, Claudia B.
Tartaglia, Maria Carmela
Ferretti, Maria Teresa
Reichelt, Lara
Probst, Philipp
Schäpers, Barbara
Müller, Friedemann
Jahn, Klaus
Plesnila, Nikolaus
Quality of life after traumatic brain injury: a cross-sectional analysis uncovers age- and sex-related differences over the adult life span
title Quality of life after traumatic brain injury: a cross-sectional analysis uncovers age- and sex-related differences over the adult life span
title_full Quality of life after traumatic brain injury: a cross-sectional analysis uncovers age- and sex-related differences over the adult life span
title_fullStr Quality of life after traumatic brain injury: a cross-sectional analysis uncovers age- and sex-related differences over the adult life span
title_full_unstemmed Quality of life after traumatic brain injury: a cross-sectional analysis uncovers age- and sex-related differences over the adult life span
title_short Quality of life after traumatic brain injury: a cross-sectional analysis uncovers age- and sex-related differences over the adult life span
title_sort quality of life after traumatic brain injury: a cross-sectional analysis uncovers age- and sex-related differences over the adult life span
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050174/
https://www.ncbi.nlm.nih.gov/pubmed/33070278
http://dx.doi.org/10.1007/s11357-020-00273-2
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