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Autonomic dysfunction following COVID-19 infection: an early experience
PURPOSE: Post-COVID-19 syndrome is a poorly understood aspect of the current pandemic, with clinical features that overlap with symptoms of autonomic/small fiber dysfunction. An early systematic analysis of autonomic dysfunction following COVID-19 is lacking and may provide initial insights into the...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050227/ https://www.ncbi.nlm.nih.gov/pubmed/33860871 http://dx.doi.org/10.1007/s10286-021-00803-8 |
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author | Shouman, Kamal Vanichkachorn, Greg Cheshire, William P. Suarez, Mariana D. Shelly, Shahar Lamotte, Guillaume J. Sandroni, Paola Benarroch, Eduardo E. Berini, Sarah E. Cutsforth-Gregory, Jeremy K. Coon, Elizabeth A. Mauermann, Michelle L. Low, Phillip A. Singer, Wolfgang |
author_facet | Shouman, Kamal Vanichkachorn, Greg Cheshire, William P. Suarez, Mariana D. Shelly, Shahar Lamotte, Guillaume J. Sandroni, Paola Benarroch, Eduardo E. Berini, Sarah E. Cutsforth-Gregory, Jeremy K. Coon, Elizabeth A. Mauermann, Michelle L. Low, Phillip A. Singer, Wolfgang |
author_sort | Shouman, Kamal |
collection | PubMed |
description | PURPOSE: Post-COVID-19 syndrome is a poorly understood aspect of the current pandemic, with clinical features that overlap with symptoms of autonomic/small fiber dysfunction. An early systematic analysis of autonomic dysfunction following COVID-19 is lacking and may provide initial insights into the spectrum of this condition. METHODS: We conducted a retrospective review of all patients with confirmed history of COVID-19 infection referred for autonomic testing for symptoms concerning for para-/postinfectious autonomic dysfunction at Mayo Clinic Rochester or Jacksonville between March 2020 and January 2021. RESULTS: We identified 27 patients fulfilling the search criteria. Symptoms developed between 0 and 122 days following the acute infection and included lightheadedness (93%), orthostatic headache (22%), syncope (11%), hyperhidrosis (11%), and burning pain (11%). Sudomotor function was abnormal in 36%, cardiovagal function in 27%, and cardiovascular adrenergic function in 7%. The most common clinical scenario was orthostatic symptoms without tachycardia or hypotension (41%); 22% of patients fulfilled the criteria for postural tachycardia syndrome (POTS), and 11% had borderline findings to support orthostatic intolerance. One patient each was diagnosed with autoimmune autonomic ganglionopathy, inappropriate sinus tachycardia, vasodepressor syncope, cough/vasovagal syncope, exacerbation of preexisting orthostatic hypotension, exacerbation of sensory and autonomic neuropathy, and exacerbation of small fiber neuropathy. CONCLUSION: Abnormalities on autonomic testing were seen in the majority of patients but were mild in most cases. The most common finding was orthostatic intolerance, often without objective hemodynamic abnormalities on testing. Unmasking/exacerbation of preexisting conditions was seen. The temporal association between infection and autonomic symptoms implies a causal relationship, which however cannot be proven by this study. |
format | Online Article Text |
id | pubmed-8050227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-80502272021-04-16 Autonomic dysfunction following COVID-19 infection: an early experience Shouman, Kamal Vanichkachorn, Greg Cheshire, William P. Suarez, Mariana D. Shelly, Shahar Lamotte, Guillaume J. Sandroni, Paola Benarroch, Eduardo E. Berini, Sarah E. Cutsforth-Gregory, Jeremy K. Coon, Elizabeth A. Mauermann, Michelle L. Low, Phillip A. Singer, Wolfgang Clin Auton Res Research Article PURPOSE: Post-COVID-19 syndrome is a poorly understood aspect of the current pandemic, with clinical features that overlap with symptoms of autonomic/small fiber dysfunction. An early systematic analysis of autonomic dysfunction following COVID-19 is lacking and may provide initial insights into the spectrum of this condition. METHODS: We conducted a retrospective review of all patients with confirmed history of COVID-19 infection referred for autonomic testing for symptoms concerning for para-/postinfectious autonomic dysfunction at Mayo Clinic Rochester or Jacksonville between March 2020 and January 2021. RESULTS: We identified 27 patients fulfilling the search criteria. Symptoms developed between 0 and 122 days following the acute infection and included lightheadedness (93%), orthostatic headache (22%), syncope (11%), hyperhidrosis (11%), and burning pain (11%). Sudomotor function was abnormal in 36%, cardiovagal function in 27%, and cardiovascular adrenergic function in 7%. The most common clinical scenario was orthostatic symptoms without tachycardia or hypotension (41%); 22% of patients fulfilled the criteria for postural tachycardia syndrome (POTS), and 11% had borderline findings to support orthostatic intolerance. One patient each was diagnosed with autoimmune autonomic ganglionopathy, inappropriate sinus tachycardia, vasodepressor syncope, cough/vasovagal syncope, exacerbation of preexisting orthostatic hypotension, exacerbation of sensory and autonomic neuropathy, and exacerbation of small fiber neuropathy. CONCLUSION: Abnormalities on autonomic testing were seen in the majority of patients but were mild in most cases. The most common finding was orthostatic intolerance, often without objective hemodynamic abnormalities on testing. Unmasking/exacerbation of preexisting conditions was seen. The temporal association between infection and autonomic symptoms implies a causal relationship, which however cannot be proven by this study. Springer Berlin Heidelberg 2021-04-16 2021 /pmc/articles/PMC8050227/ /pubmed/33860871 http://dx.doi.org/10.1007/s10286-021-00803-8 Text en © Springer-Verlag GmbH Germany, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Research Article Shouman, Kamal Vanichkachorn, Greg Cheshire, William P. Suarez, Mariana D. Shelly, Shahar Lamotte, Guillaume J. Sandroni, Paola Benarroch, Eduardo E. Berini, Sarah E. Cutsforth-Gregory, Jeremy K. Coon, Elizabeth A. Mauermann, Michelle L. Low, Phillip A. Singer, Wolfgang Autonomic dysfunction following COVID-19 infection: an early experience |
title | Autonomic dysfunction following COVID-19 infection: an early experience |
title_full | Autonomic dysfunction following COVID-19 infection: an early experience |
title_fullStr | Autonomic dysfunction following COVID-19 infection: an early experience |
title_full_unstemmed | Autonomic dysfunction following COVID-19 infection: an early experience |
title_short | Autonomic dysfunction following COVID-19 infection: an early experience |
title_sort | autonomic dysfunction following covid-19 infection: an early experience |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050227/ https://www.ncbi.nlm.nih.gov/pubmed/33860871 http://dx.doi.org/10.1007/s10286-021-00803-8 |
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