Epigenetic alteration contributes to the transcriptional reprogramming in T-cell prolymphocytic leukemia

T cell prolymphocytic leukemia (T-PLL) is a rare disease with aggressive clinical course. Cytogenetic analysis, whole-exome and whole-genome sequencing have identified primary structural alterations in T-PLL, including inversion, translocation and copy number variation. Recurrent somatic mutations w...

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Detalles Bibliográficos
Autores principales: Tian, Shulan, Zhang, Henan, Zhang, Pan, Kalmbach, Michael, Lee, Jeong-Heon, Ordog, Tamas, Hampel, Paul J., Call, Timothy G., Witzig, Thomas E., Kay, Neil E., Klee, Eric W., Slager, Susan L., Yan, Huihuang, Ding, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050249/
https://www.ncbi.nlm.nih.gov/pubmed/33859327
http://dx.doi.org/10.1038/s41598-021-87890-9

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