SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer

SOD1 is known as the major cytoplasmic superoxide dismutase and an anticancer target. However, the role of SOD1 in cancer is not fully understood. Herein we describe the generation of an inducible Sod1 knockout in KRAS-driven NSCLC mouse model. Sod1 knockout markedly reduces tumor burden in vivo and...

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Detalles Bibliográficos
Autores principales: Wang, Xiaowen, Zhang, Hong, Sapio, Russell, Yang, Jun, Wong, Justin, Zhang, Xin, Guo, Jessie Y., Pine, Sharon, Van Remmen, Holly, Li, Hong, White, Eileen, Liu, Chen, Kiledjian, Megerditch, Pestov, Dimitri G., Steven Zheng, X. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050259/
https://www.ncbi.nlm.nih.gov/pubmed/33859191
http://dx.doi.org/10.1038/s41467-021-22480-x

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