Estradiol analogs attenuate autophagy, cell migration and invasion by direct and selective inhibition of TRPML1, independent of estrogen receptors

The cation channel TRPML1 is an important regulator of lysosomal function and autophagy. Loss of TRPML1 is associated with neurodegeneration and lysosomal storage disease, while temporary inhibition of this ion channel has been proposed to be beneficial in cancer therapy. Currently available TRPML1...

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Detalles Bibliográficos
Autores principales: Rühl, Philipp, Rosato, Anna Scotto, Urban, Nicole, Gerndt, Susanne, Tang, Rachel, Abrahamian, Carla, Leser, Charlotte, Sheng, Jiansong, Jha, Archana, Vollmer, Günter, Schaefer, Michael, Bracher, Franz, Grimm, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050276/
https://www.ncbi.nlm.nih.gov/pubmed/33859333
http://dx.doi.org/10.1038/s41598-021-87817-4

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