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A longitudinal analysis of brain extracellular free water in HIV infected individuals

Initiation of combination antiretroviral therapy (cART) reduces inflammation in HIV-infected (HIV+) individuals. Recent studies demonstrated that diffusion MRI based extracellular free water (FW) modeling can be sensitive to neuroinflammation. Here, we investigate the FW in HIV-infection, its tempor...

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Autores principales: Uddin, Md Nasir, Faiyaz, Abrar, Wang, Lu, Zhuang, Yuchuan, Murray, Kyle D., Descoteaux, Maxime, Tivarus, Madalina E., Weber, Miriam T., Zhong, Jianhui, Qiu, Xing, Schifitto, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050285/
https://www.ncbi.nlm.nih.gov/pubmed/33859326
http://dx.doi.org/10.1038/s41598-021-87801-y
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author Uddin, Md Nasir
Faiyaz, Abrar
Wang, Lu
Zhuang, Yuchuan
Murray, Kyle D.
Descoteaux, Maxime
Tivarus, Madalina E.
Weber, Miriam T.
Zhong, Jianhui
Qiu, Xing
Schifitto, Giovanni
author_facet Uddin, Md Nasir
Faiyaz, Abrar
Wang, Lu
Zhuang, Yuchuan
Murray, Kyle D.
Descoteaux, Maxime
Tivarus, Madalina E.
Weber, Miriam T.
Zhong, Jianhui
Qiu, Xing
Schifitto, Giovanni
author_sort Uddin, Md Nasir
collection PubMed
description Initiation of combination antiretroviral therapy (cART) reduces inflammation in HIV-infected (HIV+) individuals. Recent studies demonstrated that diffusion MRI based extracellular free water (FW) modeling can be sensitive to neuroinflammation. Here, we investigate the FW in HIV-infection, its temporal evolution, and its association with blood markers, and cognitive scores. Using 96 age-matched participants, we found that FW was significantly elevated in grey and white matter in cART-naïve HIV+ compared to HIV-uninfected (HIV−) individuals at baseline. These increased FW values positively correlated with neurofilament light chain (NfL) and negatively correlated with CD4 counts. FW in grey and white matter, as well as NfL decreased in the HIV+ after 12 weeks of cART treatment. No significant FW differences were noted between the HIV+ and HIV− cohorts at 1 and 2-year follow-up. Results suggest that FW elevation in cART-naïve HIV+ participants is likely due to neuroinflammation. The correlation between FW and NfL, and the improvement in both FW and NfL after 12 weeks of cART treatment further reinforces this conclusion. The longer follow-up at 1 and 2 years suggests that cART helped control neuroinflammation as inferred by FW. Therefore, FW could be used as a biomarker to monitor HIV-associated neuroinflammation.
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spelling pubmed-80502852021-04-16 A longitudinal analysis of brain extracellular free water in HIV infected individuals Uddin, Md Nasir Faiyaz, Abrar Wang, Lu Zhuang, Yuchuan Murray, Kyle D. Descoteaux, Maxime Tivarus, Madalina E. Weber, Miriam T. Zhong, Jianhui Qiu, Xing Schifitto, Giovanni Sci Rep Article Initiation of combination antiretroviral therapy (cART) reduces inflammation in HIV-infected (HIV+) individuals. Recent studies demonstrated that diffusion MRI based extracellular free water (FW) modeling can be sensitive to neuroinflammation. Here, we investigate the FW in HIV-infection, its temporal evolution, and its association with blood markers, and cognitive scores. Using 96 age-matched participants, we found that FW was significantly elevated in grey and white matter in cART-naïve HIV+ compared to HIV-uninfected (HIV−) individuals at baseline. These increased FW values positively correlated with neurofilament light chain (NfL) and negatively correlated with CD4 counts. FW in grey and white matter, as well as NfL decreased in the HIV+ after 12 weeks of cART treatment. No significant FW differences were noted between the HIV+ and HIV− cohorts at 1 and 2-year follow-up. Results suggest that FW elevation in cART-naïve HIV+ participants is likely due to neuroinflammation. The correlation between FW and NfL, and the improvement in both FW and NfL after 12 weeks of cART treatment further reinforces this conclusion. The longer follow-up at 1 and 2 years suggests that cART helped control neuroinflammation as inferred by FW. Therefore, FW could be used as a biomarker to monitor HIV-associated neuroinflammation. Nature Publishing Group UK 2021-04-15 /pmc/articles/PMC8050285/ /pubmed/33859326 http://dx.doi.org/10.1038/s41598-021-87801-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Uddin, Md Nasir
Faiyaz, Abrar
Wang, Lu
Zhuang, Yuchuan
Murray, Kyle D.
Descoteaux, Maxime
Tivarus, Madalina E.
Weber, Miriam T.
Zhong, Jianhui
Qiu, Xing
Schifitto, Giovanni
A longitudinal analysis of brain extracellular free water in HIV infected individuals
title A longitudinal analysis of brain extracellular free water in HIV infected individuals
title_full A longitudinal analysis of brain extracellular free water in HIV infected individuals
title_fullStr A longitudinal analysis of brain extracellular free water in HIV infected individuals
title_full_unstemmed A longitudinal analysis of brain extracellular free water in HIV infected individuals
title_short A longitudinal analysis of brain extracellular free water in HIV infected individuals
title_sort longitudinal analysis of brain extracellular free water in hiv infected individuals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050285/
https://www.ncbi.nlm.nih.gov/pubmed/33859326
http://dx.doi.org/10.1038/s41598-021-87801-y
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